Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.38 |
| ▸ | PPARA | Q07869 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 5/20 | 0.35 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1134749 | 0.68 | PPARA (0.48) | KMT2AMAPTCYP1A2PPARAMEN1 | |
| SCHEMBL8380156 | 0.68 | CYP1A2 (0.48) | KMT2AMAPTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2432243 | 0.68 | MAPT (0.55) | KMT2AMAPTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL28376940 | 0.68 | MAPT (0.55) | KMT2AMAPTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL27757832 | 0.67 | MAPT (0.55) | KMT2AMAPTCYP1A2PPARACYP3A4 | |
| SCHEMBL3745846 | 0.67 | CYP1A2 (0.38) | KMT2AMAPTCYP1A2MEN1CYP3A4 | |
| SCHEMBL5691818 | 0.67 | PPARG (0.61) | KMT2AMAPTCYP1A2PPARAMEN1 | |
| SCHEMBL5309690 | 0.66 | PPARG (0.49) | KMT2AMAPTPPARAMEN1PPARG | |
| SCHEMBL9736278 | 0.65 | MAPT (0.47) | KMT2AMAPTCYP1A2PPARAMEN1 | |
| SCHEMBL27930895 | 0.65 | PPARA (0.46) | KMT2AMAPTCYP1A2PPARAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1372627-A1 | USE OF BREAKERS OF ADVANCED GLYCATION ENDPRODUCTS FOR TREATING DELETERIOUS EFFECTS OF AGING AND DEBILITATING DISEASES | CITY OF HOPE (US) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002076443-A1 | USE OF BREAKERS OF ADVANCED GLYCATION ENDPRODUCTS FOR TREATING DELETERIOUS EFFECTS OF AGING AND DEBILITATING DISEASES | CITY OF HOPE (US) | 2002-10-03 | — | — | WO | disclosed |