Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 7/20 | 0.38 |
| ▸ | THRA | P10827 | 6/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | ESRRA | P11474 | 1/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.35 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.35 |
| ▸ | PCNA | P12004 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3488405 | 0.89 | TDP1 (0.42) | ESR1ESR2HSD17B1HSD17B2NR4A1 | |
| SCHEMBL3487567 | 0.85 | CHEK2 (0.39) | HSD17B1HSD17B2NR4A1 | |
| SCHEMBL6543782 | 0.85 | PARP10 (0.42) | THRBTHRAESR1ESR2NR4A1 | |
| SCHEMBL3488177 | 0.85 | HSD17B1 (0.44) | HSD17B1HSD17B2NR4A1ALDH1A1MAPT | |
| SCHEMBL6543660 | 0.84 | ESRRA (0.37) | THRBTHRAPDE10AESR1AR | |
| SCHEMBL3487710 | 0.83 | MRGPRX4 (0.38) | HSD17B1HSD17B2NR4A1KMT2A | |
| SCHEMBL3488383 | 0.82 | PARP10 (0.45) | HSD17B1HSD17B2NR4A1MEN1KMT2A | |
| SCHEMBL3488037 | 0.82 | ALDH1A1 (0.39) | ARNR4A1MEN1ALDH1A1GAA | |
| SCHEMBL3487215 | 0.81 | HSD17B1 (0.52) | HSD17B1HSD17B2MEN1ALDH1A1GAA | |
| SCHEMBL3488333 | 0.81 | BRAF (0.44) | MEN1ALDH1A1MAPTBLMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1022272-B1 | SUBSTITUTED FUSED HETEROCYCLIC COMPOUNDS | SANKYO CO (JP) | 2004-05-26 | — | — | EP | disclosed |
| US-6432993-B1 | BENZIMIDAZOLE OR IMIDAZO(4,5-B)PYRIDINE DERIVATES; IMMUNOMODULATORS; ALDOSE REDUCTASE AND LIPOXYGENASE INHIBITORS; DIABETES; PREVENTS LIPID PEROXIDATION; ANTILIPEMIC, HYPOTENSIVE AGENTS | SANKYO COMPANY, LIMITED (JP) | 2002-08-13 | — | — | US | disclosed |
| EP-1022272-A1 | SUBSTITUTED FUSED HETEROCYCLIC COMPOUNDS | Sankyo Company Limited (JP) | 2000-07-26 | — | — | EP | disclosed |