Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 10/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CCND3 | P30281 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.36 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6545434 | 0.84 | CDK4 (0.45) | TTKMAPKAPK2CDK4CCNA2CCND1 | |
| SCHEMBL2863193 | 0.78 | MAPKAPK2 (0.46) | MAPKAPK2CDK4CCNA2CCND1CDK2 | |
| SCHEMBL6545436 | 0.77 | TTK (0.49) | TTKMAPKAPK2CDK4CCNA2CCND1 | |
| SCHEMBL2870195 | 0.76 | MAP2K4 (0.43) | MAPKAPK2CDK4CCNA2CCND1CDK2 | |
| SCHEMBL2857443 | 0.74 | CA12 (0.46) | MAPKAPK2CDK4CCNA2CCND1CDK2 | |
| SCHEMBL2867525 | 0.71 | ALPL (0.50) | MAPKAPK2CDK4CCNA2CCND1CDK2 | |
| SCHEMBL13198220 | 0.69 | DHODH (0.46) | CDK4CCNA2CCND1CDK2CCND3 | |
| Cyclopropanecarboxylic Acid Amide SCHEMBL2861585 | 0.69 | NPC1 (0.40) | TTKMAPKAPK2CDK4CCNA2CCND1 | |
| SCHEMBL4327031 | 0.69 | MTNR1A (0.41) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL4339304 | 0.68 | SCN9A (0.39) | TTKMAPKAPK2CDK4CCNA2CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1380576-A1 | NOVEL 1H-INDAZOLE COMPOUND | Eisai Co., Ltd. (JP) | 2004-01-14 | — | — | EP | disclosed |