Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 3/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.49 |
| ▸ | AAK1 | Q2M2I8 | 5/20 | 0.48 |
| ▸ | ULK1 | O75385 | 4/20 | 0.48 |
| ▸ | ITK | Q08881 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | CLK3 | P49761 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.44 |
| ▸ | GAK | O14976 | 1/20 | 0.44 |
| ▸ | STK16 | O75716 | 1/20 | 0.44 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2865036 | 0.84 | PDPK1 (0.65) | TTKPDPK1CSNK2A1AAK1ULK1 | |
| SCHEMBL5381639 | 0.83 | AAK1 (0.59) | TTKPDPK1CSNK2A1AAK1ULK1 | |
| SCHEMBL8254064 | 0.78 | ULK1 (0.59) | TTKPDPK1CSNK2A1AAK1ULK1 | |
| SCHEMBL5381303 | 0.76 | AAK1 (0.52) | TTKPDPK1CSNK2A1AAK1ULK1 | |
| SCHEMBL6545189 | 0.75 | MAPKAPK2 (0.46) | TTKMAPK8SYK | |
| SCHEMBL5382027 | 0.74 | MAPK10 (0.58) | TTKPDPK1CSNK2A1AAK1ULK1 | |
| SCHEMBL10214710 | 0.73 | MAPKAPK2 (0.58) | PDPK1ULK1ITK | |
| SCHEMBL5377953 | 0.72 | CLK2 (0.53) | TTKPDPK1CSNK2A1AAK1ITK | |
| SCHEMBL2871320 | 0.72 | PDPK1 (0.66) | PDPK1CSNK2A1ULK1ITKCLK2 | |
| SCHEMBL6782521 | 0.71 | PARP1 (0.60) | CSNK2A1AAK1ULK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1380576-A1 | NOVEL 1H-INDAZOLE COMPOUND | Eisai Co., Ltd. (JP) | 2004-01-14 | — | — | EP | disclosed |