Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 7/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | GSK3B | P49841 | 3/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.47 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.47 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.47 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | EEF2K | O00418 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6545953 | 0.91 | BIRC5 (0.46) | CYP2C9CYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL8482450 | 0.88 | CYP2C9 (0.57) | CYP2C9CYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL6545662 | 0.87 | GSK3B (0.49) | GSK3BCDK5CCNB2CDK1CCNB1 | |
| SCHEMBL6544425 | 0.87 | CYP2C9 (0.72) | CYP2C9CYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL6545441 | 0.81 | GSK3B (0.60) | CYP2C9CYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL6545364 | 0.79 | CYP2C9 (0.62) | CYP2C9CYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL6545382 | 0.78 | FASN (0.53) | GSK3BCDK5CCNB2CDK1CCNB1 | |
| SCHEMBL24095739 | 0.77 | CYP2C9 (0.47) | CYP2C9CYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL5415892 | 0.76 | CYP2C9 (0.71) | CYP2C9CYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL24095759 | 0.76 | PADI4 (0.55) | CYP2C9CYP1A2CYP3A4CYP2C19CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0942723-B1 | 4-ARYL-3-HYDROXYQUINOLIN-2-ONE DERIVATIVES AS ION CHANNEL MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2004-01-21 | — | — | EP | claimed |
| US-5922735-A | CALCIUM-ACTIVATED POTASSIUM CHANNELS AND ARE USEFUL TREATING THE DISORDER RESPONSIVE TO THE OPENING OF THE POTASSIUM CHANNELS SUCH AS ISCHEMIA, CONVULSIONS, ASTHMA, IRRITABLE BOWEL SYNDROME, MIGRAINE, TRAUMATIC BRAIN INJURY | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-07-13 | — | — | US | claimed |
| US-5892045-A | 4-aryl-3-hydroxyquinolin-2-one derivatives as ion channel modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-04-06 | — | — | US | claimed |