Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BIRC5 | O15392 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.42 |
| ▸ | JUN | P05412 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6545356 | 0.91 | CYP2C9 (0.56) | BIRC5CYP2C9CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL6545364 | 0.86 | CYP2C9 (0.62) | BIRC5CYP2C9CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL6545662 | 0.79 | GSK3B (0.49) | CA12CA9MAPTMEN1KMT2A | |
| SCHEMBL8482450 | 0.79 | CYP2C9 (0.57) | BIRC5CYP2C9CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL6544425 | 0.77 | CYP2C9 (0.72) | BIRC5CYP2C9CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL14969141 | 0.75 | CA12 (0.51) | CYP2C9CYP1A2CYP3A4CYP2C19CA12 | |
| SCHEMBL8480429 | 0.74 | CYP2C9 (0.62) | BIRC5CYP2C9CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL6545441 | 0.72 | GSK3B (0.60) | BIRC5CYP2C9CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL6546279 | 0.71 | EEF2K (0.71) | CYP1A2CYP3A4CYP2D6MEN1KMT2A | |
| SCHEMBL3275049 | 0.71 | CYP2C9 (0.86) | BIRC5CYP2C9CYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0942723-B1 | 4-ARYL-3-HYDROXYQUINOLIN-2-ONE DERIVATIVES AS ION CHANNEL MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2004-01-21 | — | — | EP | claimed |
| US-5922735-A | CALCIUM-ACTIVATED POTASSIUM CHANNELS AND ARE USEFUL TREATING THE DISORDER RESPONSIVE TO THE OPENING OF THE POTASSIUM CHANNELS SUCH AS ISCHEMIA, CONVULSIONS, ASTHMA, IRRITABLE BOWEL SYNDROME, MIGRAINE, TRAUMATIC BRAIN INJURY | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-07-13 | — | — | US | claimed |
| US-5892045-A | 4-aryl-3-hydroxyquinolin-2-one derivatives as ion channel modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-04-06 | — | — | US | claimed |