Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 1/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.52 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.52 |
| ▸ | PARP1 | P09874 | 2/20 | 0.51 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | CDK1 | P06493 | 3/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.48 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.48 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.48 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.45 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.45 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.45 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 3/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6545662 | 0.86 | GSK3B (0.49) | CDK5CDK5R1CA12CA9CDK1 | |
| SCHEMBL6545441 | 0.78 | GSK3B (0.60) | CDK5GSK3BGSK3ACDK2IKBKB | |
| SCHEMBL6545356 | 0.78 | CYP2C9 (0.56) | CDK5CDK5R1CDK1GSK3BCCNB1 | |
| SCHEMBL8479093 | 0.75 | CDK2 (0.52) | FASNCDK5CDK5R1PARP1CA12 | |
| SCHEMBL20920125 | 0.74 | GABRA1 (0.59) | CDK5CDK5R1PARP1CA12CA9 | |
| SCHEMBL21828647 | 0.73 | CTSV (0.70) | CDK5CDK5R1PARP1CA12CA9 | |
| SCHEMBL9389021 | 0.72 | PARP1 (0.60) | FASNPARP1CA12CA9CDK1 | |
| SCHEMBL8895896 | 0.72 | GRIN2D (0.66) | FASNPARP1CA12CA9GRIA1 | |
| SCHEMBL8896143 | 0.71 | GRIN2D (0.64) | FASNCDK5CDK5R1GSK3BGSK3A | |
| SCHEMBL6545953 | 0.71 | BIRC5 (0.46) | CDK5CDK5R1CA12CA9CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0942723-B1 | 4-ARYL-3-HYDROXYQUINOLIN-2-ONE DERIVATIVES AS ION CHANNEL MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2004-01-21 | — | — | EP | claimed |
| EP-0942723-A4 | 4-ARYL-3-HYDROXYQUINOLIN-2-ONE DERIVATIVES AS ION CHANNEL MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2002-05-15 | — | — | EP | claimed |
| EP-0942723-A1 | 4-ARYL-3-HYDROXYQUINOLIN-2-ONE DERIVATIVES AS ION CHANNEL MODULATORS | Bristol-Myers Squibb Company (US) | 1999-09-22 | — | — | EP | claimed |
| US-5922735-A | CALCIUM-ACTIVATED POTASSIUM CHANNELS AND ARE USEFUL TREATING THE DISORDER RESPONSIVE TO THE OPENING OF THE POTASSIUM CHANNELS SUCH AS ISCHEMIA, CONVULSIONS, ASTHMA, IRRITABLE BOWEL SYNDROME, MIGRAINE, TRAUMATIC BRAIN INJURY | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-07-13 | — | — | US | claimed |
| US-5892045-A | 4-aryl-3-hydroxyquinolin-2-one derivatives as ion channel modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-04-06 | — | — | US | claimed |
| WO-1998023273-A1 | 4-ARYL-3-HYDROXYQUINOLIN-2-ONE DERIVATIVES AS ION CHANNEL MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-06-04 | — | — | WO | claimed |