Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6546182 | 0.90 | MAPT (0.44) | NPSR1SMN1; SMN2GAALMNAMAPT | |
| SCHEMBL6545334 | 0.83 | SMN1; SMN2 (0.42) | NPSR1SMN1; SMN2GAAMAPTTRPM8 | |
| SCHEMBL7201570 | 0.70 | ADAM17 (0.38) | NPSR1SMN1; SMN2GAAHTTLMNA | |
| SCHEMBL6545932 | 0.67 | LMNA (0.43) | SMN1; SMN2GAAHTTLMNAMAPT | |
| SCHEMBL2624372 | 0.66 | GAA (0.62) | NPSR1GAALMNAMAPTTRPM8 | |
| SCHEMBL8417819 | 0.65 | SMN1; SMN2 (0.47) | NPSR1SMN1; SMN2GAAHTTMAPT | |
| SCHEMBL31488094 | 0.65 | MAPT (0.53) | NPSR1SMN1; SMN2GAAHTTMAPT | |
| SCHEMBL8421528 | 0.65 | SMN1; SMN2 (0.61) | NPSR1SMN1; SMN2GAALMNAMAPT | |
| SCHEMBL15063418 | 0.64 | PPARA (0.56) | NPSR1GAALMNAKDM4EALDH1A1 | |
| SCHEMBL6773891 | 0.64 | TSHR (0.47) | NPSR1SMN1; SMN2GAAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379533-A2 | NOVEL CYCLO AZAPHOSPHA HYDROCARBONS | Leo Pharma A/S (DK) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002083696-A2 | NOVEL CYCLO AZAPHOSPHA HYDROCARBONS | LEO PHARMA A/S (DK) | 2002-10-24 | — | — | WO | disclosed |