Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 8/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | FGB | P02675 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | IDH1 | O75874 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 8/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6545779 | 0.89 | MAPT (0.48) | HSD17B10CYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL6545261 | 0.88 | ALOX15 (0.42) | HSD17B10CYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL6545609 | 0.88 | MEN1 (0.42) | HSD17B10CYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL6545099 | 0.85 | KDM4E (0.50) | HSD17B10CYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL6545503 | 0.79 | MEN1 (0.37) | HSD17B10CYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL7750822 | 0.76 | KDM4E (0.50) | HSD17B10CYP2C19MAPTALOX15MEN1 | |
| SCHEMBL12217647 | 0.65 | BRD4 (0.43) | HSD17B10CYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL16268752 | 0.63 | SNCA (0.42) | HSD17B10MAPTALOX15MEN1KMT2A | |
| SCHEMBL10434586 | 0.62 | KDM4E (0.41) | HSD17B10CYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL16276933 | 0.62 | MAOA (0.43) | HSD17B10MAPTALOX15MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1027055-B1 | 3-CARBOALKOXY-2,3-DIHYDRO-1H-PHENOTHIAZIN-4(10H)-ONE DERIVATIVES | UNIV HOWARD (US) | 2004-01-07 | — | — | EP | disclosed |
| EP-1027055-A4 | 3-CARBOALKOXY-2,3-DIHYDRO-1H-PHENOTHIAZIN-4(10H)-ONE DERIVATIVES | UNIV HOWARD (US) | 2001-12-05 | — | — | EP | disclosed |
| EP-1027055-A1 | 3-CARBOALKOXY-2,3-DIHYDRO-1H-PHENOTHIAZIN-4(10H)-ONE DERIVATIVES | HOWARD UNIVERSITY (US) | 2000-08-16 | — | — | EP | disclosed |
| US-5994349-A | ANTIEPILEPTIC AGENTS | HOWARD UNIVERSITY (US) | 1999-11-30 | — | — | US | disclosed |
| WO-1999021560-A1 | 3-CARBOALKOXY-2,3-DIHYDRO-1H-PHENOTHIAZIN-4[10H]-ONE DERIVATIVES | HOWARD UNIVERSITY (US) | 1999-05-06 | — | — | WO | disclosed |