SCHEMBL6545546

SCHEMBL6545546

CCCCC(Cl)C(=O)Nc1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.61
MAPT P10636 4/20 0.61
MEN1 O00255 3/20 0.61
KMT2A Q03164 3/20 0.61
SMN1; SMN2 Q16637 2/20 0.61
MAPK1 P28482 1/20 0.61
GAA P10253 2/20 0.54
ATM Q13315 2/20 0.54
LMNA P02545 1/20 0.54
HSD17B10 Q99714 1/20 0.52
HDAC8 Q9BY41 7/20 0.52
HDAC3 O15379 5/20 0.52
HDAC6 Q9UBN7 5/20 0.52
HDAC1 Q13547 4/20 0.52
HDAC2 Q92769 4/20 0.52
HDAC4 P56524 2/20 0.52
HDAC7 Q8WUI4 2/20 0.52
HDAC10 Q969S8 2/20 0.52
HDAC11 Q96DB2 2/20 0.52
HDAC9 Q9UKV0 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10629250 0.95 ALDH1A1 (0.56) ALDH1A1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL8769265 0.90 MAPT (0.57) ALDH1A1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL7099035 0.83 MEN1 (0.78) ALDH1A1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL6901453 0.83 MAPT (0.61) ALDH1A1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL28855894 0.82 ALDH1A1 (0.62) ALDH1A1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL5524304 0.82 ALDH1A1 (0.67) ALDH1A1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL6370477 0.82 ALDH1A1 (0.56) ALDH1A1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL27709662 0.81 ALDH1A1 (0.54) ALDH1A1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL9267426 0.81 MEN1 (0.61) ALDH1A1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL5264997 0.81 MEN1 (0.61) ALDH1A1MAPTMEN1KMT2ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6733947-B2 MAMMOGRAMS; WELL DEFINED CHARACTERISTIC CURVE AFTER RAPID DEVELOPING AGFA-GEVAERT (BE) 2004-05-11 US disclosed
US-20040009423-A1 Diagnostic radiographic silver halide photographic film material AGFA HEALTHCARE (BE) 2004-01-15 US disclosed
EP-1378791-A1 Diagnostic radiographic silver halide photographic film material Agfa-Gevaert (BE) 2004-01-07 EP disclosed
US-4567264-A ADRENERGIC BLOCKING AGENTS SYNTEX (U.S.A.) INC. (US) 1986-01-28 US disclosed
US-4499100-A CARDIOUVASCULAR DISORDERS SYNTEX (U.S.A.) INC. (US) 1985-02-12 US disclosed