SCHEMBL8769265

SCHEMBL8769265

CCCC(Cl)C(=O)Nc1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.57
ALDH1A1 P00352 5/20 0.57
GAA P10253 2/20 0.57
ATM Q13315 2/20 0.57
LMNA P02545 1/20 0.57
HSP90AA1 P07900 2/20 0.54
GPR55 Q9Y2T6 1/20 0.54
MEN1 O00255 4/20 0.53
KMT2A Q03164 4/20 0.53
SMN1; SMN2 Q16637 3/20 0.53
HPGD P15428 2/20 0.53
HTT P42858 1/20 0.53
MAPK1 P28482 1/20 0.52
NPC1 O15118 1/20 0.51
RAB9A P51151 1/20 0.51
RXFP1 Q9HBX9 1/20 0.49
POLB P06746 1/20 0.49
TSHR P16473 2/20 0.48
HSD17B10 Q99714 1/20 0.48
METAP2 P50579 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6545546 0.90 ALDH1A1 (0.61) MAPTALDH1A1GAAATMLMNA
SCHEMBL10629250 0.89 ALDH1A1 (0.56) MAPTALDH1A1GAAATMLMNA
SCHEMBL6901453 0.86 MAPT (0.61) MAPTALDH1A1GAAATMLMNA
SCHEMBL29484002 0.85 MEN1 (0.50) ALDH1A1GAAATMLMNAGPR55
SCHEMBL30033784 0.85 MAPT (0.53) MAPTALDH1A1MEN1KMT2ANPC1
SCHEMBL27709662 0.84 ALDH1A1 (0.54) MAPTALDH1A1GAAATMLMNA
SCHEMBL20621920 0.82 MEN1 (0.65) MAPTALDH1A1MEN1KMT2ASMN1; SMN2
SCHEMBL1701248 0.82 MAPT (0.53) MAPTALDH1A1GAAATMLMNA
SCHEMBL1491201 0.81 HSD17B10 (0.69) MAPTALDH1A1GAAATMLMNA
SCHEMBL8570404 0.80 MAPT (0.58) MAPTALDH1A1GAAATMLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0784431-A1 SYNERGISTIC ACTIVE SUBSTANCE HERBICIDE COMBINATIONS WITH 1-(2,6-DICHLORO-4-DIFLUOROMETHYL-PHENYL)-5-(2-CHLOROPROPIONAMIDO)-4-NITROPYRAZOL BAYER AG (DE) 1997-07-23 EP claimed
WO-1996010333-A1 SYNERGISTIC ACTIVE SUBSTANCE HERBICIDE COMBINATIONS WITH 1-(2,6-DICHLORO-4-DIFLUOROMETHYL-PHENYL)-5-(2-CHLOROPROPIONAMIDO)-4-NITROPYRAZOL BAYER AKTIENGESELLSCHAFT (DE) 1996-04-11 WO claimed