Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 9/20 | 0.70 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.70 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.70 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.70 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.70 |
| ▸ | HTR2A | P28223 | 1/20 | 0.70 |
| ▸ | HTR2C | P28335 | 1/20 | 0.70 |
| ▸ | DRD4 | P21917 | 1/20 | 0.64 |
| ▸ | TSPO | P30536 | 1/20 | 0.64 |
| ▸ | DRD3 | P35462 | 1/20 | 0.64 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6545626 | 0.91 | ADORA3 (0.60) | ADORA3ADORA1ADORA2AADORA2BCHRM5 | |
| SCHEMBL6281497 | 0.91 | ADORA3 (0.71) | ADORA3ADORA1ADORA2AADORA2BCHRM5 | |
| SCHEMBL6546460 | 0.91 | ADORA3 (0.71) | ADORA3ADORA1ADORA2AADORA2BCHRM5 | |
| SCHEMBL6548193 | 0.90 | ADORA3 (0.58) | ADORA3ADORA1ADORA2AADORA2BCHRM5 | |
| SCHEMBL6282312 | 0.85 | ADORA3 (0.73) | ADORA3ADORA1ADORA2AADORA2BCHRM5 | |
| SCHEMBL6546907 | 0.82 | ADORA3 (0.92) | ADORA3ADORA1ADORA2AADORA2BCHRM5 | |
| SCHEMBL18230421 | 0.82 | ADORA1 (0.62) | ADORA3ADORA1ADORA2AADORA2BCHRM5 | |
| SCHEMBL6286082 | 0.82 | ADORA3 (1.00) | ADORA3ADORA1ADORA2AADORA2BCHRM5 | |
| SCHEMBL6282412 | 0.82 | ADORA1 (0.59) | ADORA3ADORA1ADORA2AADORA2BCHRM5 | |
| SCHEMBL6546759 | 0.81 | ALDH1A1 (0.62) | ADORA3ADORA1ADORA2AADORA2BCHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1027050-B1 | 1,3-THIAZOLES AS ADENOSINE A3 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF ALLERGY, ASTHMA AND DIABETES | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-01-14 | — | — | EP | disclosed |
| US-6620825-B1 | 1,3-Azole compound substituted by pyridyl; administering as antiasthmatic, antiinflammatory or antiallergen agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-09-16 | — | — | US | disclosed |
| US-6436966-B1 | Adenosine A3 receptor antagonists | TAKEDA CHEMICAL IND., LTD. (JP) | 2002-08-20 | — | — | US | disclosed |
| EP-1027050-A2 | ADENOSINE A3 RECEPTOR ANTAGONISTS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-16 | — | — | EP | disclosed |
| WO-1999021555-A2 | ADENOSINE A3 RECEPTOR ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-05-06 | — | — | WO | disclosed |