Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 6/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6546199 | 0.92 | MEN1 (0.52) | ABL1PIK3CDADORA3ADORA2BADORA2A | |
| SCHEMBL6546278 | 0.91 | ABL1 (0.54) | ABL1PIK3CDADORA3ADORA2BADORA2A | |
| SCHEMBL6545775 | 0.88 | PIK3CD (0.49) | ABL1PIK3CDKDM4EALDH1A1LMNA | |
| SCHEMBL6546255 | 0.87 | ALDH1A1 (0.51) | ADORA3ADORA2BADORA2AADORA1KDM4E | |
| SCHEMBL6285228 | 0.86 | MAPT (0.63) | ABL1ADORA3ADORA2BKDM4EALDH1A1 | |
| SCHEMBL6546759 | 0.85 | ALDH1A1 (0.62) | PIK3CDADORA3ADORA2BADORA2AADORA1 | |
| SCHEMBL6546919 | 0.83 | ABL1 (0.45) | ABL1PIK3CDADORA3ADORA2BADORA2A | |
| SCHEMBL6546095 | 0.82 | XIAP (0.53) | ADORA3ADORA2BADORA2AADORA1KDM4E | |
| SCHEMBL6281626 | 0.82 | ADORA3 (0.63) | ABL1ADORA3ADORA2BADORA2AADORA1 | |
| SCHEMBL6545626 | 0.80 | ADORA3 (0.60) | ADORA3ADORA2BADORA2AADORA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1027050-B1 | 1,3-THIAZOLES AS ADENOSINE A3 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF ALLERGY, ASTHMA AND DIABETES | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-01-14 | — | — | EP | disclosed |
| US-6620825-B1 | 1,3-Azole compound substituted by pyridyl; administering as antiasthmatic, antiinflammatory or antiallergen agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-09-16 | — | — | US | disclosed |
| US-6436966-B1 | Adenosine A3 receptor antagonists | TAKEDA CHEMICAL IND., LTD. (JP) | 2002-08-20 | — | — | US | disclosed |