Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzyl Salicylate SCHEMBL29411199 | 0.94 | TDP1 (0.75) | TDP1ALDH1A1HTTMCL1KMT2A | |
| SCHEMBL4415350 | 0.90 | HTT (0.75) | TDP1ALDH1A1HTTKMT2ASMN1; SMN2 | |
| SCHEMBL9574717 | 0.88 | HTT (0.73) | TDP1ALDH1A1HTTKMT2ASMN1; SMN2 | |
| Benzyl Salicylate SCHEMBL8669653 | 0.88 | TDP1 (0.90) | TDP1ALDH1A1KMT2ASMN1; SMN2POLB | |
| SCHEMBL11153597 | 0.86 | TDP1 (0.66) | TDP1ALDH1A1HTTKMT2ASMN1; SMN2 | |
| SCHEMBL10617749 | 0.84 | ALDH1A1 (0.69) | TDP1ALDH1A1HTTKMT2ASMN1; SMN2 | |
| Benzyl Salicylate SCHEMBL15573 | 0.83 | TDP1 (1.00) | TDP1ALDH1A1KMT2APOLBRAB9A | |
| Benzyl Salicylate SCHEMBL1871397 | 0.83 | TDP1 (1.00) | TDP1ALDH1A1KMT2APOLBRAB9A | |
| Benzyl Salicylate SCHEMBL30184766 | 0.83 | TDP1 (1.00) | TDP1ALDH1A1KMT2APOLBRAB9A | |
| SCHEMBL8356074 | 0.83 | TDP1 (0.79) | TDP1ALDH1A1HTTKMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1381347-A1 | ANTIPERSPIRANT ACTIVES FROM A GLASS FORM AND PRODUCTS MADE THEREWITH | Colgate-Palmolive Company (US) | 2004-01-21 | — | — | EP | disclosed |
| WO-2002085321-A1 | ANTIPERSPIRANT ACTIVES FROM A GLASS FORM AND PRODUCTS MADE THEREWITH | COLGATE-PALMOLIVE COMPANY (US) | 2002-10-31 | — | — | WO | disclosed |