SCHEMBL6547372

SCHEMBL6547372

COc1ccccc1N=C(c1ccccc1)c1ccccc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOS3 P29474 2/20 0.50
NOS1 P29475 2/20 0.50
NOS2 P35228 2/20 0.50
GRIN2D O15399 1/20 0.50
GRIN3B O60391 1/20 0.50
GRIN1 Q05586 1/20 0.50
GRIN2A Q12879 1/20 0.50
GRIN2B Q13224 1/20 0.50
GRIN2C Q14957 1/20 0.50
GRIN3A Q8TCU5 1/20 0.50
SIGMAR1 Q99720 1/20 0.50
GAA P10253 1/20 0.46
CA1 P00915 2/20 0.44
CA2 P00918 2/20 0.44
ESR1 P03372 2/20 0.44
ESR2 Q92731 2/20 0.44
CA12 O43570 1/20 0.44
CA4 P22748 1/20 0.44
CA7 P43166 1/20 0.44
CA9 Q16790 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30416262 1.00 NOS3 (0.50) NOS3NOS1NOS2GRIN2DGRIN3B
SCHEMBL16098463 0.90 ALDH1A1 (0.56) NOS3NOS1NOS2GRIN2DGRIN3B
SCHEMBL16096960 0.87 ALDH1A1 (0.44) NOS3NOS1NOS2GRIN2DGRIN3B
SCHEMBL16098066 0.86 HTT (0.41) NOS3NOS1NOS2GRIN2DGRIN3B
SCHEMBL16096483 0.86 CYP1A1 (0.50) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL16098113 0.86 HTT (0.41) NOS3NOS1NOS2GRIN2DGRIN3B
SCHEMBL16097131 0.85 SMN1; SMN2 (0.45) NOS3NOS1NOS2GRIN2DGRIN3B
SCHEMBL15136502 0.83 ALDH1A1 (0.51) NOS3NOS1NOS2GRIN2DGRIN3B
SCHEMBL15136503 0.83 ALDH1A1 (0.51) NOS3NOS1NOS2GRIN2DGRIN3B
SCHEMBL15003926 0.83 ALDH1A1 (0.51) NOS3NOS1NOS2GRIN2DGRIN3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1100774-B1 IMPROVED ARYLAMINE SYNTHESIS MASSACHUSETTS INST TECHNOLOGY (US) 2004-01-21 EP disclosed
US-6323366-B1 ACTIVATED ARYL GROUP AND AN IMINE GROUP ARE COMBINED, IN THE PRESENCE OF A TRANSITION METAL CATALYST FOR FORMATION OF A CARBON-NITROGEN BOND BETWEEN THE ACTIVATED CARBON OF THE ARENE AND IMINE NITROGEN; CONVERTING TO ARYLAMINE MASSACHUSETTS INSTITUTE OF TECHNOLOGY 2001-11-27 US disclosed
EP-1100774-A1 IMPROVED ARYLAMINE SYNTHESIS MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2001-05-23 EP disclosed
WO-2000005199-A1 IMPROVED ARYLAMINE SYNTHESIS MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2000-02-03 WO disclosed