SCHEMBL6547416

SCHEMBL6547416

Cl[Zr](Cl)(Cl)C1c2ccccc2-c2ccccc21

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR3 P46089 2/20 0.41
HTR2A P28223 2/20 0.41
SLC22A2 O15244 1/20 0.36
SLC22A3 O75751 1/20 0.36
HDAC3 O15379 1/20 0.35
HDAC4 P56524 1/20 0.35
HDAC7 Q8WUI4 1/20 0.35
HDAC8 Q9BY41 1/20 0.35
HDAC6 Q9UBN7 1/20 0.35
HDAC9 Q9UKV0 1/20 0.35
HDAC5 Q9UQL6 1/20 0.35
NCOR2 Q9Y618 1/20 0.35
POLB P06746 2/20 0.34
CYP1A2 P05177 1/20 0.34
CYP2D6 P10635 1/20 0.34
ACHE P22303 3/20 0.33
BCHE P06276 2/20 0.33
S100A4 P26447 1/20 0.33
CHRM2 P08172 1/20 0.33
HTR1A P08908 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL796784 0.84 GPR3 (0.41) GPR3HTR2ASLC22A2SLC22A3HDAC3
SCHEMBL28586502 0.77 HTR2A (0.35) GPR3HTR2ASLC22A2SLC22A3HDAC3
SCHEMBL20440936 0.74 GPR3 (0.41) GPR3HTR2ASLC22A2SLC22A3HDAC3
SCHEMBL7602124 0.74 GPR3 (0.46) GPR3HTR2ASLC22A2SLC22A3HDAC3
SCHEMBL20480846 0.73 GPR3 (0.33) GPR3HTR2ASLC22A2SLC22A3
SCHEMBL9350868 0.70 GPR3 (0.42) GPR3HTR2ASLC22A2SLC22A3HDAC3
SCHEMBL8755331 0.70 HTR2A (0.38) GPR3HTR2AHDAC3HDAC4HDAC7
SCHEMBL5343918 0.69 GPR3 (0.46) GPR3HTR2ASLC22A2SLC22A3HDAC3
SCHEMBL7189284 0.69 GPR3 (0.33) GPR3SLC22A2SLC22A3
SCHEMBL31266545 0.69 GPR3 (0.46) GPR3HTR2ASLC22A2SLC22A3HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0908468-B1 Process for the (co)polymerisation of olefins SOLVAY (BE) 2004-05-26 EP disclosed
EP-0857735-B1 Process for producing a catalyst system and process for the (co) polymerization of olefins SOLVAY (BE) 2004-01-21 EP disclosed
US-6555632-B1 Homo or copolymerization of alpha-olefin in presence of a catalyst system containing neutral halogenated metallocene catalyst, an organoaluminum compound, and an ionizing agent SOLVAY POLYOLEFINS EUROPE-BELGIUM (SOCIETE ANONYME) (BE) 2003-04-29 US disclosed
US-6214948-B1 PLACING A SOLID PRECURSOR CONTAINING AT LEAST ONE NEUTRAL METALLOCENE DERIVED FROM TRANSITIONAL METAL AND AN IONIZING AGENT, IN CONTACT WITH ORGANOMETALLIC COMPOUND OF 1A, 2A, 2B, 3 AND 4 GROUP SOLVAY POLYOLEFINS EUROPE-BELGIUM (BE) 2001-04-10 US disclosed
US-6013595-A A CATALYTIC SOLID FOR THE (CO)POLYMERIZATION OF ETHYLENE, COMPRISING AT LEAST ONE INORGANIC SUPPORT, A TRANSITION METAL METALLOCENE, ATLEAST ONE IONIZATING AGENT AND A CHROMIUM COMPOUND SOLVAY (SOCIETE ANONYME) (BE) 2000-01-11 US disclosed
EP-0602716-B1 Catalyst system, process for its production and its use in (co)polymerization of olefins SOLVAY (BE) 1999-12-15 EP disclosed
EP-0733650-B1 Solid catalyst for (co)polymerizing ethylene, process for its preparation, catalyst system for the (co)polymerization of ethylene and process for the (co)polymerization of ethylene SOLVAY (BE) 1999-05-12 EP disclosed
EP-0908468-A2 Process for the (co)polymerisation of olefins SOLVAY POLYOLEFINS EUROPE - BELGIUM (Société Anonyme) (BE) 1999-04-14 EP disclosed
US-5817725-A Process for the preparation of a catalytic system, process for the (CO) polymerization of olefins and (CO) polymers of at least one olefin SOLVAY POLYOLEFINS EUROPE-BELGIUM (SOCIETE ANONYME) (BE) 1998-10-06 US disclosed
EP-0857735-A2 Process for producing a catalyst system, process for the (co) polymerization of olefins and (co) polymers of at least one olefin SOLVAY POLYOLEFINS EUROPE - BELGIUM (Société Anonyme) (BE) 1998-08-12 EP disclosed
EP-0613908-B1 Solid precursor of a catalytic system for polymerization of olefins, process for its preparation and catalytic system containing said precursor SOLVAY (BE) 1998-07-29 EP disclosed
US-5763349-A Solid precursor of a catalytic system for the polymerization of olefins, process for its preparation, catalytic system comprising this solid precursor and process for the polymerization of olefins in the presence of this catalytic system SOLVAY POLYOLEFINS EUROPE - BELGIUM (BE) 1998-06-09 US disclosed
EP-0838476-A1 Solid precursor of a catalyst system for polymerization of olefins, process for its preparation and catalytic system containing said precursor and process for the polymerization of olefins using said catalyst system SOLVAY POLYOLEFINS EUROPE - BELGIUM (Société Anonyme) (BE) 1998-04-29 EP disclosed
US-5719235-A Catalyst system, use of this catalyst system for the (co)polymerization of olefins, process for preparing this catalyst system and olefin (co)polymerization process SOLVAY (SOCIETE ANONYME) (BE) 1998-02-17 US disclosed
US-5612271-A Process for the prepration of a catalytic system, process for the (co)polymerization of olefins and (co)polymers of at least one olefin SOLVAY (SOCIETE ANONYME) (BE) 1997-03-18 US disclosed
EP-0733650-A1 Solid catalyst for (co)polymerizing ethylene, process for its preparation, catalyst system for the (co)polymerization of ethylene and process for the (co)polymerization of ethylene SOLVAY (Société Anonyme) (BE) 1996-09-25 EP disclosed
US-5496782-A Catalyst system, use of this catalyst system for the (co)polymerization of olefins, process for preparing this catalyst system and olefin (co) polymerization process Solvay (Socie/ te/ Anonyme) (BE) 1996-03-05 US disclosed
EP-0613908-A1 Solid precursor of a catalytic system for polymerization of olefins, process for its preparation and catalytic system containing said precursor SOLVAY (Société Anonyme) (BE) 1994-09-07 EP disclosed
EP-0602716-A1 Catalyst system, process for its production and its use in (co)polymerization of olefins SOLVAY (Société Anonyme) (BE) 1994-06-22 EP disclosed
EP-0573120-A1 Process for producing a catalyst system, process for the (co)polymerization of olefins and (co)polymers of at least one olefin SOLVAY (Société Anonyme) (BE) 1993-12-08 EP disclosed