SCHEMBL6547472

SCHEMBL6547472

Cn1c(CC(=O)O)cnc1-c1ccc(-c2ccccc2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 1/20 0.50
CYP11B2 P19099 1/20 0.50
PTGS1 P23219 2/20 0.46
ABCC4 O15439 1/20 0.46
LMNA P02545 1/20 0.46
GAA P10253 1/20 0.46
TSHR P16473 1/20 0.46
HTT P42858 1/20 0.46
COMT P21964 1/20 0.46
HPGDS O60760 1/20 0.44
KMT2A Q03164 2/20 0.44
RXRA P19793 1/20 0.44
RXRB P28702 1/20 0.44
ESR1 P03372 1/20 0.42
DHODH Q02127 1/20 0.42
CDC25A P30304 1/20 0.41
CDC25B P30305 1/20 0.41
HSD11B1 P28845 2/20 0.40
FFAR1 O14842 1/20 0.40
MEN1 O00255 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Potassium SCHEMBL8852787 0.81 CYP11B1 (0.52) CYP11B1CYP11B2COMTHPGDSKMT2A
SCHEMBL10961092 0.81 L3MBTL1 (0.48) CYP11B1CYP11B2LMNATSHRKDM4E
SCHEMBL8728777 0.80 PTGS1 (0.44) PTGS1ABCC4LMNAGAATSHR
SCHEMBL10652845 0.79 CYP11B1 (0.45) CYP11B1CYP11B2LMNAGAACOMT
SCHEMBL1314931 0.79 CYP11B1 (0.56) CYP11B1CYP11B2GAACOMTHPGDS
SCHEMBL14382243 0.77 CYP11B1 (0.57) CYP11B1CYP11B2GAATSHRCOMT
SCHEMBL6547461 0.77 AVPR1A (0.45) PTGS1ABCC4LMNAGAATSHR
SCHEMBL4879887 0.76 COMT (0.49) CYP11B1CYP11B2COMTHPGDSKMT2A
SCHEMBL27470055 0.76 CYP11B1 (0.45) CYP11B1CYP11B2GAAHTTCOMT
SCHEMBL6977000 0.76 CYP11B1 (0.56) CYP11B1CYP11B2GAATSHRCOMT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0748315-B1 USE OF IMIDAZOLE DERIVATIVES FOR TREATING DISORDERS INVOLVING ANGIOTENSIN RECEPTORS AT1 AND AT2, THESE PRODUCTS, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AVENTIS PHARMA SA (FR) 2004-01-07 EP claimed
EP-0748314-B1 TETRASUBSTITUTED IMIDAZOLE DERIVATIVES, METHOD FOR PREPARING THE SAME, USE THEREOF AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AVENTIS PHARMA SA (FR) 2002-05-15 EP claimed
US-5811445-A ANGIOTENSIN II INHIBITORS ROUSSEL UCLAF (FR) 1998-09-22 US disclosed
US-5807878-A CARDIOVASCULAR DISORDERS Uclaf, Roussel (FR) 1998-09-15 US disclosed