Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | OXTR | P30559 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5823683 | 0.84 | AVPR1A (0.49) | AVPR1AOXTRMEN1KMT2AALDH1A1 | |
| SCHEMBL4879878 | 0.78 | AVPR1A (0.49) | AVPR1AHTTOXTRRXRAPTGS2 | |
| SCHEMBL6547472 | 0.77 | CYP11B1 (0.50) | PTGS1HTTABCC4LMNAGAA | |
| SCHEMBL8669619 | 0.75 | AVPR1A (0.46) | AVPR1AHTTOXTRALDH1A1MAPT | |
| SCHEMBL6593121 | 0.72 | AVPR1A (0.53) | AVPR1AHTTTSHROXTRPTGS2 | |
| SCHEMBL2789865 | 0.71 | CYP2C19 (0.58) | HTTLMNATSHRMEN1KMT2A | |
| SCHEMBL8666696 | 0.70 | AVPR1A (0.41) | AVPR1AHTTOXTRPTGS2ALDH1A1 | |
| SCHEMBL27535437 | 0.70 | AVPR1A (0.42) | AVPR1AHTTLMNATSHRMEN1 | |
| SCHEMBL8735101 | 0.70 | AVPR1A (0.58) | AVPR1AHTTOXTRRXRAALDH1A1 | |
| SCHEMBL8728777 | 0.69 | PTGS1 (0.44) | PTGS1HTTABCC4LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0748315-B1 | USE OF IMIDAZOLE DERIVATIVES FOR TREATING DISORDERS INVOLVING ANGIOTENSIN RECEPTORS AT1 AND AT2, THESE PRODUCTS, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2004-01-07 | — | — | EP | claimed |
| EP-0748314-B1 | TETRASUBSTITUTED IMIDAZOLE DERIVATIVES, METHOD FOR PREPARING THE SAME, USE THEREOF AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | AVENTIS PHARMA SA (FR) | 2002-05-15 | — | — | EP | claimed |
| US-5811445-A | ANGIOTENSIN II INHIBITORS | ROUSSEL UCLAF (FR) | 1998-09-22 | — | — | US | disclosed |
| US-5807878-A | CARDIOVASCULAR DISORDERS | Uclaf, Roussel (FR) | 1998-09-15 | — | — | US | disclosed |