Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.37 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | FGF2 | P09038 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6547554 | 1.00 | POLB (0.39) | POLBLCKPPARDZDHHC20ZDHHC2 | |
| SCHEMBL7461005 | 0.89 | LCK (0.43) | POLBLCKPPARDZDHHC20ZDHHC2 | |
| SCHEMBL7461000 | 0.89 | LCK (0.43) | POLBLCKPPARDZDHHC20ZDHHC2 | |
| SCHEMBL7460994 | 0.89 | LCK (0.43) | POLBLCKPPARDZDHHC20ZDHHC2 | |
| SCHEMBL3132426 | 0.80 | ALDH1A1 (0.39) | LCKPPARDZDHHC20ZDHHC2ALDH1A1 | |
| SCHEMBL6546386 | 0.78 | TET2 (0.40) | POLBALDH1A1PKMMEN1KMT2A | |
| SCHEMBL6546396 | 0.78 | TET2 (0.40) | POLBALDH1A1PKMMEN1KMT2A | |
| SCHEMBL3938395 | 0.77 | CYP1A2 (0.47) | POLBALDH1A1PKMMEN1KMT2A | |
| SCHEMBL7079225 | 0.74 | ALDH1A1 (0.41) | POLBALDH1A1TSHRPKMMEN1 | |
| SCHEMBL2464552 | 0.73 | POLB (0.42) | POLBALDH1A1PKMMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6818622-B2 | ADMINISTERING OVER A PERIOD OF AT LEAST THREE MONTHS A MATRIX METALLOPROTEINASE INHIBITOR FOR TREATMENT OF A PATIENT HAVING CANCER OR INFLAMMATION | DARWIN DISCOVERY LTD. (GB) | 2004-11-16 | — | — | US | disclosed |
| EP-0981366-B1 | SELECTIVE MMP INHIBITORS HAVING REDUCED SIDE-EFFECTS | DARWIN DISCOVERY LTD (GB) | 2004-01-21 | — | — | EP | disclosed |
| US-20020035065-A1 | Selective MMP inhibitors having reduced side-effects | BIRD JOHN (GB) | 2002-03-21 | — | — | US | disclosed |
| EP-0981366-A1 | SELECTIVE MMP INHIBITORS HAVING REDUCED SIDE-EFFECTS | Darwin Discovery Limited (GB) | 2000-03-01 | — | — | EP | disclosed |
| WO-1998039024-A1 | SELECTIVE MMP INHIBITORS HAVING REDUCED SIDE-EFFECTS | DARWIN DISCOVERY LIMITED (GB) | 1998-09-11 | — | — | WO | disclosed |