Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 known ✓ | Q9BY41 | 1/20 | 0.37 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL440492 | 0.87 | NAPRT (1.00) | NAPRTKDM4EGAAMAPTDAO | |
| Hydrochloric Acid SCHEMBL14741024 | 0.85 | NAPRT (0.96) | NAPRTKDM4EGAAMAPTDAO | |
| Hydrochloric Acid SCHEMBL17597625 | 0.85 | NAPRT (0.96) | NAPRTKDM4EGAAMAPTDAO | |
| Azetidine SCHEMBL9393520 | 0.79 | NAPRT (0.81) | NAPRTKDM4EGAAMAPTDAO | |
| Trifluoroacetic Acid SCHEMBL17595211 | 0.77 | NAPRT (0.79) | NAPRTKDM4EGAAMAPTDAO | |
| Phthalic Acid SCHEMBL28654022 | 0.77 | ALDH1A1 (0.67) | NAPRTKDM4EMAPTALDH1A1ALOX15 | |
| Phthalic Acid SCHEMBL28071671 | 0.75 | ALDH1A1 (0.64) | NAPRTKDM4EMAPTALDH1A1ALOX15 | |
| Phthalic Acid SCHEMBL28056982 | 0.74 | ALDH1A1 (0.61) | NAPRTKDM4EMAPTALDH1A1ALOX15 | |
| SCHEMBL3182033 | 0.74 | NAPRT (0.67) | NAPRTKDM4EGAAMAPTDAO | |
| SCHEMBL425117 | 0.73 | NAPRT (0.72) | NAPRTKDM4EGAAMAPTDAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1044688-B1 | METHOD FOR SOLUBILIZING PYRIDONECARBOXYLIC ACIDS AND AQUEOUS SOLUTIONS CONTAINING PYRIDONECARBOXYLIC ACIDS | SENJU PHARMA CO (JP) | 2004-12-01 | — | — | EP | disclosed |
| EP-0856316-B1 | Method for solubilizing pyridonecarboxylic acids comprising the use of an arylcarboxylic acid as solubilizer | SENJU PHARMA CO (JP) | 2003-05-07 | — | — | EP | disclosed |
| US-6306856-B1 | DISSOLVING PYRIDONECARBOXYLIC ACID OR SALT, MIXING WITH GLYCYRRHIZIC ACID WITH ACID | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2001-10-23 | — | — | US | disclosed |
| EP-1044688-A1 | METHOD FOR SOLUBILIZING PYRIDONECARBOXYLIC ACID, SOLUBILIZER THEREFOR, AQUEOUS SOLUTION PREPARATIONS CONTAINING PYRIDONECARBOXYLIC ACID AND PROCESS FOR PRODUCING THE SAME | Senju Pharmaceutical Co., Ltd. (JP) | 2000-10-18 | — | — | EP | disclosed |
| US-5942508-A | Method for solubilizing pyridonecarboxylic acid solubilizer thereof and aqueous solution containing solubilized pyridonecarboxylic acid | SENJU PHARMACEUTICAL CO., LTD. (JP) | 1999-08-24 | — | — | US | disclosed |
| EP-0856316-A1 | Method for solubilizing pyridonecarboxylic acid, solubilizer thereof and aqueous solution containing solubilized pyridonecarboxylic acid | Senju Pharmaceutical Co., Ltd. (JP) | 1998-08-05 | — | — | EP | disclosed |