Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | ACP1 | P24666 | 2/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3306010 | 0.84 | ACP1 (0.55) | TRPA1LMNAHPGDSMN1; SMN2ACP1 | |
| SCHEMBL6548460 | 0.82 | DAO (0.43) | TRPA1GAADAOALDH1A1LMNA | |
| Bromide SCHEMBL6556197 | 0.79 | SIRT2 (0.41) | TRPA1GAADAOSIRT2CYP19A1 | |
| SCHEMBL4966803 | 0.78 | PNP (0.50) | ALDH1A1POLBSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL25426121 | 0.77 | PNP (0.49) | ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL7120147 | 0.75 | DAO (0.40) | TRPA1GAADAOSIRT2ALDH1A1 | |
| SCHEMBL8509077 | 0.72 | SMN1; SMN2 (0.47) | TRPA1ALDH1A1LMNAMAPTHPGD | |
| SCHEMBL6797064 | 0.71 | GAA (0.43) | TRPA1GAASIRT2ALDH1A1POLB | |
| SCHEMBL7111737 | 0.71 | PNP (0.49) | TRPA1DAOALDH1A1HPGDSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6258586 | 0.70 | PNP (0.48) | TRPA1DAOALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383766-A1 | DISUBSTITUTED 1,7-GUANINES | Pharmacia Italia S.p.A. (IT) | 2004-01-28 | — | — | EP | claimed |
| WO-2002090357-A1 | DISUBSTITUTED 1,7-GUANINES | PHARMACIA ITALIA S.P.A. (IT) | 2002-11-14 | — | — | WO | claimed |
| EP-1383766-A1 | DISUBSTITUTED 1,7-GUANINES | Pharmacia Italia S.p.A. (IT) | 2004-01-28 | — | — | EP | disclosed |
| WO-2002090357-A1 | DISUBSTITUTED 1,7-GUANINES | PHARMACIA ITALIA S.P.A. (IT) | 2002-11-14 | — | — | WO | disclosed |