Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | APAF1 | O14727 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL464725 | 0.90 | HCAR2 (0.45) | HCAR2CYP2D6ALDH1A1LMNA | |
| SCHEMBL27685764 | 0.83 | HCAR2 (0.41) | HCAR2CYP2D6ALDH1A1LMNA | |
| SCHEMBL27332949 | 0.83 | ALDH1A1 (0.49) | HCAR2KMT2ACYP2D6SRCFFAR1 | |
| SCHEMBL28702688 | 0.83 | ALDH1A1 (0.49) | HCAR2KMT2ACYP2D6SRCFFAR1 | |
| SCHEMBL871942 | 0.82 | HCAR2 (0.59) | HCAR2KMT2ACYP2D6SRCFFAR1 | |
| SCHEMBL9566873 | 0.81 | HCAR2 (0.44) | HCAR2KMT2ACYP2D6FFAR1ALDH1A1 | |
| SCHEMBL5431494 | 0.80 | HCAR2 (0.42) | HCAR2CYP2D6ALDH1A1LMNAALOX5 | |
| SCHEMBL22169 | 0.80 | LMNA (0.57) | HCAR2KMT2AALDH1A1CYP3A4APAF1 | |
| SCHEMBL3786370 | 0.79 | HCAR2 (0.61) | HCAR2KMT2ACYP2D6SRCFFAR1 | |
| SCHEMBL3625234 | 0.79 | HCAR2 (0.61) | HCAR2KMT2ACYP2D6SRCFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0909767-B1 | Packing and distillation methods for inhibiting polymerization of vinyl compound | MITSUBISHI GAS CHEMICAL CO (JP) | 2004-02-04 | — | — | EP | disclosed |
| US-6239199-B1 | DISTILLATION TOWER CONTAINING PACKING; POLYOLEFIN, A FLUORORESIN, A POLYESTER, A POLYAMIDE, A POLYCARBONATE AND A POLYETHER | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2001-05-29 | — | — | US | disclosed |
| EP-0909767-A1 | Resin composition and distillation methods for inhibiting polymerization of vinyl compound | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 1999-04-21 | — | — | EP | disclosed |
| EP-0380662-B1 | METHOD OF MANUFACTURING DRAW-FORMED CONTAINER | TOYO SEIKAN KAISHA LTD (JP) | 1994-09-07 | — | — | EP | disclosed |
| US-5048317-A | Method of manufacturing draw-formed container | TOYO SEIKAN KAISHA LTD. (JP) | 1991-09-17 | — | — | US | disclosed |
| EP-0380662-A1 | METHOD OF MANUFACTURING DRAW-FORMED CONTAINER | TOYO SEIKAN KAISHA, LTD. (JP) | 1990-08-08 | — | — | EP | disclosed |
| US-4877662-A | MULTILAYER ETHYLENE-VINYL ALCOHOL AND PROPYLENE OR CARBONYL-CONTAINING THERMOPLASTIC RESIN AND HYDROXIDE, OXIDE, SILICATE, OR ACID SALT STABILIZER | TOYO SEIKAN KAISHA, LTD. (JP) | 1989-10-31 | — | — | US | disclosed |
| US-4387830-A | Side seam-coated tinplate welded can | TOYO SEIKAN KAISHA, LTD. (JP) | 1983-06-14 | — | — | US | disclosed |
| US-4384657-A | CHROMIUM AND CHROMIUM OXIDE LAYERS, MAGNETITE, COATING OF RESIN WITH POLAR GROUP | TOYO SEIKAN KAISHA LTD. (JP) | 1983-05-24 | — | — | US | disclosed |