SCHEMBL654918

SCHEMBL654918

O=C1N=C2N=CC=C2NC1=O

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11303901 0.78
SCHEMBL6746850 0.65 GABRA1 (0.31)
SCHEMBL7455261 0.63
SCHEMBL9051617 0.60
SCHEMBL6550578 0.55
SCHEMBL7569561 0.49
SCHEMBL7409317 0.49
SCHEMBL11769613 0.48
SCHEMBL1887298 0.47
SCHEMBL4721785 0.47

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119390722-B Organic small molecular compound capable of distinguishing and detecting hydrazine and hypochlorite and preparation method thereof 华南理工大学 2025-10-17 CN disclosed
CN-119390722-A Organic small molecular compound capable of distinguishing and detecting hydrazine and hypochlorite and preparation method thereof 华南理工大学 2025-02-07 CN disclosed
CN-108884470-B HPPD variants and methods of use 巴斯夫农业种子解决方案美国有限责任公司 2023-07-25 CN disclosed
US-10913790-B2 Compositions of, and methods for, alpha-1 anti trypsin Fc fusion molecules THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) 2021-02-09 US disclosed
US-20200206328-A1 COMPOSITIONS, METHODS AND USES OF ALPHA 1-ANTITRYPSIN FOR EARLY INTERVENTION IN BONE MARROW TRANSPLANTATION AND TREATMENT OF GRAFT VERSUS HOST DISEASE UNIV COLORADO REGENTS (US) 2020-07-02 US disclosed
US-20200079836-A1 COMPOSITIONS OF, AND METHODS FOR, ALPHA-1 ANTI TRYPSIN Fc FUSION MOLECULES THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE 2020-03-12 US disclosed
US-20180133294-A1 COMPOSITIONS AND METHODS RELATED TO GRAFT VERSUS HOST DISEASE AND TREATMENTS THEREOF THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE 2018-05-17 US disclosed
US-9884096-B2 Compositions and methods related to graft versus host disease and treatments thereof THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) 2018-02-06 US disclosed
US-20170240615-A1 COMPOSITIONS OF, AND METHODS FOR, ALPHA-1 ANTITRYPSIN Fc FUSION MOLECULES THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE 2017-08-24 US disclosed
EP-1909810-B2 INHIBITORS OF SERINE PROTEASE ACTIVITY AND THEIR USE IN METHODS AND COMPOSITIONS FOR TREATMENT OF GRAFT REJECTION AND PROMOTION OF GRAFT SURVIVAL UNIV COLORADO REGENTS (US) 2017-08-23 EP disclosed
WO-2005040194-A2 METHODS AND COMPOSITIONS FOR PDGF-C ACTIVATION AND INHIBITION LUDWIG INSTITUTE FOR CANCER RESEARCH (US) 2005-05-06 WO disclosed
US-6849605-B1 Inhibitors of serine protease activity, methods and compositions for treatment of viral infections THE TRUSTEES OF UNIVERSITY TECHNOLOGY CORPORATION (US) 2005-02-01 US disclosed
US-20040220239-A1 Inhibitors of serine protease activity methods and compositions for treatment of nitric oxide-induced clinical conditions BIO HOLDING, INC. 2004-11-04 US disclosed
US-20040220242-A1 Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions BIO HOLDING, INC. 2004-11-04 US disclosed
US-20040220113-A1 Inhibitors of serine protease activity methods and compositions for treatment of nitric oxide-induced clinical conditions BIO HOLDING, INC. 2004-11-04 US disclosed
US-6489308-B1 ONE AGENT EXHIBITING MAMMALIAN ALPHA 1-ANTITRYPSIN OR ALPHA 1-ANTITRYPSIN-LIKE ACTIVITY, AND A FREE RADICAL SCAVENGER SUCH AS 2,6,8-TRIHYDROXYPURINE, DIHYDRORHODAMINE, OR A COMBINATION THEREOF TRUSTEES OF UNIVERSITY OF TECHNOLOGY CORPORATION 2002-12-03 US disclosed
US-6124291-A TREATING AND PREVENTING THROMBOTIC DISORDERS WARNER-LAMBERT COMPANY (US) 2000-09-26 US disclosed
WO-2000052034-A2 INHIBITORS OF SERINE PROTEASE ACTIVITY, METHODS AND COMPOSITIONS FOR TREATMENT OF VIRAL INFECTIONS THE TRUSTEES OF UNIVERSITY TECHNOLOGY CORPORATION (US) 2000-09-08 WO disclosed
WO-2000051623-A2 INHIBITORS OF SERINE PROTEASE ACTIVITY, METHODS AND COMPOSITIONS FOR TREATMENT OF NITRIC OXIDE-INDUCED CLINICAL CONDITIONS THE TRUSTEES OF UNIVERSITY TECHNOLOGY CORPORATION (US) 2000-09-08 WO disclosed
WO-1997048706-A1 PYRROLO[1,2-A]PYRAZINE-1,4-DIONE SERINE PROTEASE INHIBITORS WARNER-LAMBERT COMPANY (US) 1997-12-24 WO disclosed