SCHEMBL6549280

SCHEMBL6549280

Cc1cc(NCC=Cc2cc(N)ccc2N)ccc1N

nearest known ligand 0.39

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.39
CYP3A4 P08684 3/20 0.39
TDP1 Q9NUW8 3/20 0.39
THRB P10828 1/20 0.39
ALOX15 P16050 1/20 0.39
RECQL P46063 1/20 0.39
HIF1A Q16665 1/20 0.39
CASP1 P29466 1/20 0.33
TSHR P16473 1/20 0.33
S100B P04271 1/20 0.31
SKP2 Q13309 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6549279 1.00 ALDH1A1 (0.39) ALDH1A1CYP3A4TDP1THRBALOX15
Hydrochloric Acid SCHEMBL6750466 0.99 ALDH1A1 (0.38) ALDH1A1CYP3A4TDP1THRBALOX15
Hydrochloric Acid SCHEMBL6750469 0.99 ALDH1A1 (0.38) ALDH1A1CYP3A4TDP1THRBALOX15
SCHEMBL5171488 0.90 CASP1 (0.43) ALDH1A1CYP3A4TDP1RECQLCASP1
SCHEMBL5171483 0.90 CASP1 (0.43) ALDH1A1CYP3A4TDP1RECQLCASP1
SCHEMBL461181 0.86 APP (0.38) ALDH1A1CYP3A4TDP1ALOX15
SCHEMBL461180 0.86 APP (0.38) ALDH1A1CYP3A4TDP1ALOX15
Hydrochloric Acid SCHEMBL6750536 0.85 APP (0.37) ALDH1A1
Hydrochloric Acid SCHEMBL6750531 0.85 APP (0.37) ALDH1A1
SCHEMBL6550255 0.83 CYP3A4 (0.38) ALDH1A1CYP3A4TDP1THRBALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6699296-B2 Mixture containing phenylenediamine developer WELLA AKTIENGESELLSCHAFT (DE) 2004-03-02 US claimed
EP-1183227-B1 P-DIAMINOBENZENE DERIVATIVES AND DYES CONTAINING SAID COMPOUNDS WELLA AG (DE) 2004-02-04 EP claimed
US-20030145764-A1 P-diaminobenzene derivatives and dyes containing said compounds WELLA INTERNATIONAL OPERATIONS SWITZERLAND SARL (CH) 2003-08-07 US claimed
US-6699296-B2 Mixture containing phenylenediamine developer WELLA AKTIENGESELLSCHAFT (DE) 2004-03-02 US disclosed
EP-1183227-B1 P-DIAMINOBENZENE DERIVATIVES AND DYES CONTAINING SAID COMPOUNDS WELLA AG (DE) 2004-02-04 EP disclosed
US-20030145764-A1 P-diaminobenzene derivatives and dyes containing said compounds WELLA INTERNATIONAL OPERATIONS SWITZERLAND SARL (CH) 2003-08-07 US disclosed
EP-1183227-A1 P-DIAMINOBENZENE DERIVATIVES AND DYES CONTAINING SAID COMPOUNDS Wella Aktiengesellschaft (DE) 2002-03-06 EP disclosed
WO-2001072686-A1 P-DIAMINOBENZENE DERIVATIVES AND DYES CONTAINING SAID COMPOUNDS WELLA AKTIENGESELLSCHAFT (DE) 2001-10-04 WO disclosed