Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | FAAH | O00519 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.33 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.32 |
| ▸ | FDPS | P14324 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL5552338 | 1.00 | TSHR (0.44) | TSHRALDH1A1FAAHTDP1EPHX1 | |
| Bromide SCHEMBL7902920 | 1.00 | TSHR (0.44) | TSHRALDH1A1FAAHTDP1EPHX1 | |
| Bromide SCHEMBL7904765 | 1.00 | TSHR (0.44) | TSHRALDH1A1FAAHTDP1EPHX1 | |
| Bromide SCHEMBL8469019 | 1.00 | TSHR (0.44) | TSHRALDH1A1FAAHTDP1EPHX1 | |
| Bromide SCHEMBL8468747 | 1.00 | TSHR (0.44) | TSHRALDH1A1FAAHTDP1EPHX1 | |
| Bromide SCHEMBL5551009 | 0.94 | TSHR (0.48) | TSHRALDH1A1FAAHTDP1EPHX1 | |
| Bromide SCHEMBL5547772 | 0.94 | TSHR (0.48) | TSHRALDH1A1FAAHTDP1EPHX1 | |
| SCHEMBL9207849 | 0.86 | EPHX1 (0.44) | TSHRALDH1A1EPHX1FDPSTHRB | |
| SCHEMBL21236821 | 0.86 | EPHX1 (0.44) | TSHRALDH1A1EPHX1FDPSTHRB | |
| SCHEMBL8755205 | 0.86 | EPHX1 (0.44) | TSHRALDH1A1EPHX1FDPSTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1014999-B1 | CATIONIC POLYMERS AS TOXIN-BINDING AGENTS | GENZYME CORP (US) | 2004-12-08 | — | — | EP | disclosed |
| US-6692732-B2 | Administering cationic polymers to mammals to prevent poisons or antigens from microorganisms such as bacteria, viruses, fungi or parasites; deactivation | GENZYME CORPORATION | 2004-02-17 | — | — | US | disclosed |
| US-20040009145-A1 | IONIC POLYMERS AS TOXIN-BINDING AGENTS | GELTEX PHARMACEUTICALS, INC. | 2004-01-15 | — | — | US | disclosed |
| US-6482402-B1 | BACTERICIDE AND CATIONIC POLYMER | GELTEX PHARMACEUTICALS, INC. | 2002-11-19 | — | — | US | disclosed |
| US-20020114774-A1 | Ionic polymers as toxin-binding agents | GELTEX PHARMACEUTICALS, INC. | 2002-08-22 | — | — | US | disclosed |
| US-6290947-B1 | IN ONE EMBODIMENT, THE POLYMER IS A COPOLYMER COMPRISING A MONOMER HAVING A PENDANT AMMONIUM GROUP AND A HYDROPHOBIC MONOMER. | GELTEX PHARMACEUTICALS, INC. | 2001-09-18 | — | — | US | disclosed |
| EP-1014999-A1 | CATIONIC POLYMERS AS TOXIN-BINDING AGENTS | GELTEX PHARMACEUTICALS, INC. (US) | 2000-07-05 | — | — | EP | disclosed |
| US-5969090-A | QUATERNIZED CROSSLINKED HYDROCARBON AMINE POLYMER | GELTEX PHARMACEUTICALS, INC. (US) | 1999-10-19 | — | — | US | disclosed |
| US-5900475-A | MODIFIED POLYALLYLAMINE; ANTICHOLESTEROL AGENT | GELTEX PHARMACEUTICALS, INC. (US) | 1999-05-04 | — | — | US | disclosed |
| WO-1999015186-A1 | CATIONIC POLYMERS AS TOXIN-BINDING AGENTS | GELTEX PHARMACEUTICALS, INC. (US) | 1999-04-01 | — | — | WO | disclosed |
| EP-0830390-A1 | HYDROPHOBIC HETEROATOM-CONTAINING SEQUESTRANT FOR CHOLESTEROL DEPLETION | GELTEX PHARMACEUTICALS, INC. (US) | 1998-03-25 | — | — | EP | disclosed |
| WO-1996039449-A1 | HYDROPHOBIC HETEROATOM-CONTAINING SEQUESTRANT FOR CHOLESTEROL DEPLETION | GELTEX PHARMACEUTICALS, INC. (US) | 1996-12-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020114774-A1 | Ionic polymers as toxin-binding agents | PIGS, ANTXR2, MSN | TSHR 622/4885ALDH1A1 4693/4885FAAH 3533/4885 |
| US-20040009145-A1 | IONIC POLYMERS AS TOXIN-BINDING AGENTS | PIGS, ANTXR2, MSN | TSHR 622/4885ALDH1A1 4693/4885FAAH 3533/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.