Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2880149 | 0.89 | HDAC7 (0.42) | HDAC7HDAC8HDAC6HDAC9HDAC5 | |
| SCHEMBL22304191 | 0.85 | CA2 (0.46) | CA1CA2 | |
| SCHEMBL2952253 | 0.85 | CA2 (0.46) | CA1CA2 | |
| SCHEMBL2954534 | 0.85 | CA2 (0.46) | CA1CA2 | |
| SCHEMBL24378364 | 0.83 | MAPK1 (0.47) | HDAC7HDAC8HDAC6HDAC9HDAC5 | |
| SCHEMBL2874052 | 0.82 | ALDH1A1 (0.35) | HDAC7HDAC8HDAC6HDAC9HDAC5 | |
| SCHEMBL12215228 | 0.80 | CA1 (0.44) | HDAC7HDAC8HDAC6HDAC9HDAC5 | |
| SCHEMBL29205058 | 0.79 | CA2 (0.41) | CA2 | |
| SCHEMBL29205057 | 0.79 | CA2 (0.41) | CA2 | |
| SCHEMBL29205059 | 0.79 | CA2 (0.41) | CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1176138-B1 | Active derivatives of valproic acid for the treatment of neurological and psychotic disorders and a method for their preparation | YISSUM RES DEV CO (IL) | 2004-12-01 | — | — | EP | claimed |
| EP-1176138-B1 | Active derivatives of valproic acid for the treatment of neurological and psychotic disorders and a method for their preparation | YISSUM RES DEV CO (IL) | 2004-12-01 | — | — | EP | disclosed |
| EP-1176138-A1 | Active derivatives of valproic acid for the treatment of neurological and psychotic disorders and a method for their preparation | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2002-01-30 | — | — | EP | disclosed |
| US-6323365-B1 | FOR THERAPY OF CONVULSIONS AND EPILEPSY, AND FOR THE TREATMENT OF PAIN AND MIGRAINE, BIPOLAR DISORDER | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2001-11-27 | — | — | US | disclosed |