SCHEMBL6550609

SCHEMBL6550609

c1ccc(COc2ccc(Oc3csc4ccccc34)cc2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.47
CYP1A2 P05177 1/20 0.47
PTGS1 P23219 1/20 0.47
SLC6A2 P23975 1/20 0.47
CYP2C19 P33261 1/20 0.47
PTGS2 P35354 1/20 0.47
SLC6A3 Q01959 1/20 0.47
HIF1A Q16665 1/20 0.47
HDAC6 Q9UBN7 1/20 0.47
MAOB P27338 4/20 0.46
RAB9A P51151 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
GAA P10253 1/20 0.46
MAPT P10636 1/20 0.46
MAOA P21397 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
BCHE P06276 1/20 0.44
NR4A1 P22736 1/20 0.43
NR4A2 P43354 1/20 0.43
NR4A3 Q92570 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27469411 0.84 MAPT (0.46) LMNACYP1A2PTGS1SLC6A2CYP2C19
SCHEMBL30445394 0.84 MAOB (0.47) LMNACYP1A2PTGS1SLC6A2CYP2C19
SCHEMBL25729137 0.84 MAOB (0.42) LMNACYP1A2PTGS1SLC6A2CYP2C19
SCHEMBL25242610 0.84 MAOB (0.47) LMNACYP1A2PTGS1SLC6A2CYP2C19
SCHEMBL6550614 0.84 MAPT (0.44) RAB9ASMN1; SMN2MAPTL3MBTL1NPC1
SCHEMBL7918745 0.83 ALOX5 (0.41) LMNACYP1A2PTGS1SLC6A2CYP2C19
SCHEMBL30065511 0.82 CYP2A6 (0.42) LMNAHDAC6MAOBRAB9AGAA
SCHEMBL24792264 0.82 CYP2A6 (0.42) LMNAHDAC6MAOBRAB9AGAA
SCHEMBL25232524 0.81 NR4A2 (0.57) MAOBRAB9ASMN1; SMN2NR4A1NR4A2
SCHEMBL30445244 0.81 NR4A2 (0.57) MAOBRAB9ASMN1; SMN2NR4A1NR4A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0838462-B1 Benzothiophene compounds, intermediates, compositions, and methods LILLY CO ELI (US) 2004-02-11 EP disclosed
EP-0827959-B1 Benzo[B]thiophene compounds, intermediates, processes, compositions, and methods LILLY CO ELI (US) 2003-12-03 EP disclosed
EP-0729956-B1 Benzothiophene compounds, intermediates, compositions, and methods LILLY CO ELI (US) 2001-10-31 EP disclosed
EP-1113013-A1 Benzothiophene compounds, intermediates, compositions and methods Eli Lilly & Company (US) 2001-07-04 EP disclosed
US-6197790-B1 OSTEOPOROSIS ELI LILLY AND COMPANY 2001-03-06 US disclosed
US-6030986-A POST-MENOPAUSAL SYNDROME, UTERINE FIBROID DISEASE, ENDOMETRIOSIS, AND AORTAL SMOOTH MUSCLE CELL PROLIFERATION; ESTROGEN INDUCED UTERINE CANCER; OSTEOPOROSIS; RESTENOSIS; CARDIOVASCULAR DISORDERS ELI LILLY AND COMPANY (US) 2000-02-29 US disclosed
US-5998441-A ANTICHOLESTEROL AGENT; MIXTURE WITH ESTROGEN ELI LILLY AND COMPANY (US) 1999-12-07 US disclosed
US-5985897-A METHODS OF INHIBITING BONE LOSS OR BONE RESORPTION, PARTICULARLY OSTEOPOROSIS, AND CARDIOVASCULAR-RELATED PATHOLOGICAL CONDITIONS, INCLUDING HYPERLIPIDEMIA, AND ESTROGEN-DEPENDENT CANCER ELI LILLY AND COMPANY 1999-11-16 US disclosed
US-5986109-A UROGENITAL DISORDERS, CARDIOVASCULAR DISORDERS AND ANTICARCINOGENIC AGENTS ELI LILLY AND COMPANY (US) 1999-11-16 US disclosed
US-5985898-A INHIBITING HYPERLIPIDEMIA RESULTED FROM ESTROGEN DEFICIENCY DISEASE, REDUCING SERUM CHOLESTEROL, ELI LILLY AND COMPANY (US) 1999-11-16 US disclosed
US-5843965-A Benzo B! thiophene compounds, intermediates, processes, compositions, and methods ELI LILLY AND COMPANY (US) 1998-12-01 US disclosed
EP-0838462-A1 Benzothiophene compounds, intermediates, compositions, and methods ELI LILLY AND COMPANY (US) 1998-04-29 EP disclosed
EP-0827959-A2 Benzo[B]thiophene compounds, intermediates, processes, compositions, and methods ELI LILLY AND COMPANY (US) 1998-03-11 EP disclosed
US-5723474-A TREATING POST-MENOPAUSAL SYNDROME, UTERINE FIBROID DISEASE, ENDOMETRIOSIS, AND AORTAL SMOOTH MUSCLE CELL PROLIFERATION; ANTIESTROGENS ELI LILLY AND COMPANY (US) 1998-03-03 US disclosed
EP-0729956-A1 Benzothiophene compounds, intermediates, compositions, and methods ELI LILLY AND COMPANY (US) 1996-09-04 EP disclosed
US-5510357-A POST-MENOPAUSAL SYNDROME, ENDOMETRIOSIS ELI LILLY AND COMPANY (US) 1996-04-23 US disclosed
US-5510358-A OSTEOPOROSIS ELI LILLY AND COMPANY (US) 1996-04-23 US disclosed
US-5510498-A Benzothiophene compounds, intermediates, compositions, and methods ELI LILLY AND COMPANY (US) 1996-04-23 US disclosed
US-5492922-A PREVENTING RESTENOSIS ELI LILLY AND COMPANY (US) 1996-02-20 US disclosed
US-5488058-A UROGENITAL DISORDERS OR OSTEOPOROSIS ELI LILLY AND COMPANY (US) 1996-01-30 US disclosed