SCHEMBL7918745

SCHEMBL7918745

Ic1cc(OCc2ccccc2)ccc1Oc1csc2ccccc12

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.41
MAOB P27338 8/20 0.40
FFAR1 O14842 3/20 0.39
MAOA P21397 2/20 0.38
CYP3A4 P08684 1/20 0.38
CTSV O60911 1/20 0.38
CTSL P07711 1/20 0.38
TNKS2 Q9H2K2 1/20 0.37
PARP2 Q9UGN5 1/20 0.37
PTP4A3 O75365 1/20 0.37
LMNA P02545 1/20 0.37
CYP1A2 P05177 1/20 0.37
PTGS1 P23219 1/20 0.37
SLC6A2 P23975 1/20 0.37
CYP2C19 P33261 1/20 0.37
PTGS2 P35354 1/20 0.37
SLC6A3 Q01959 1/20 0.37
HIF1A Q16665 1/20 0.37
HDAC6 Q9UBN7 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6550609 0.83 LMNA (0.47) ALOX5MAOBFFAR1MAOALMNA
SCHEMBL7927596 0.80 NPSR1 (0.47) MAOBFFAR1PTP4A3LMNA
SCHEMBL6550614 0.79 MAPT (0.44) PTP4A3
SCHEMBL7926823 0.77 GSTP1 (0.39) ALOX5MAOBFFAR1MAOAPTP4A3
SCHEMBL27469411 0.77 MAPT (0.46) MAOBPTP4A3LMNACYP1A2PTGS1
SCHEMBL25242610 0.72 MAOB (0.47) ALOX5MAOBMAOATNKS2PARP2
SCHEMBL25729137 0.72 MAOB (0.42) ALOX5MAOBFFAR1MAOALMNA
SCHEMBL30445394 0.72 MAOB (0.47) ALOX5MAOBMAOATNKS2PARP2
SCHEMBL6234342 0.71 MAOB (0.51) ALOX5MAOBFFAR1MAOACYP3A4
SCHEMBL8147590 0.70 ALOX5 (0.49) ALOX5MAOBFFAR1LMNACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0729956-B1 Benzothiophene compounds, intermediates, compositions, and methods LILLY CO ELI (US) 2001-10-31 EP disclosed
EP-1113013-A1 Benzothiophene compounds, intermediates, compositions and methods Eli Lilly & Company (US) 2001-07-04 EP disclosed
US-6197790-B1 OSTEOPOROSIS ELI LILLY AND COMPANY 2001-03-06 US disclosed
US-6030986-A POST-MENOPAUSAL SYNDROME, UTERINE FIBROID DISEASE, ENDOMETRIOSIS, AND AORTAL SMOOTH MUSCLE CELL PROLIFERATION; ESTROGEN INDUCED UTERINE CANCER; OSTEOPOROSIS; RESTENOSIS; CARDIOVASCULAR DISORDERS ELI LILLY AND COMPANY (US) 2000-02-29 US disclosed
US-5998441-A ANTICHOLESTEROL AGENT; MIXTURE WITH ESTROGEN ELI LILLY AND COMPANY (US) 1999-12-07 US disclosed
US-5985898-A INHIBITING HYPERLIPIDEMIA RESULTED FROM ESTROGEN DEFICIENCY DISEASE, REDUCING SERUM CHOLESTEROL, ELI LILLY AND COMPANY (US) 1999-11-16 US disclosed
US-5986109-A UROGENITAL DISORDERS, CARDIOVASCULAR DISORDERS AND ANTICARCINOGENIC AGENTS ELI LILLY AND COMPANY (US) 1999-11-16 US disclosed
US-5981765-A FOR TREATMENT OF POST-MENOPAUSAL SYNDROME INCLUDING OSTEOPOROSIS, CARDIOVASCULAR EFFECTS SUCH AS HYPERLIPIDEMIA, AND ESTROGEN-DEPENDENT CANCER, PARTICULARLY BREAST AND UTERINE CANCER ELI LILLY AND COMPANY (US) 1999-11-09 US disclosed
US-5977093-A INHIBITING ESTROGEN-DEPENDENT CANCER ELI LILLY AND COMPANY (US) 1999-11-02 US disclosed
US-5969142-A OXIDIZING SULFUR ATOM OF SUBSTITUTED BENZOTHIOPHENE, REACTING PRODUCT WITH NUCLEOPHILIC GROUP, REDUCING PRODUCT TO DESIRED COMPOUND ELI LILLY AND COMPANY (US) 1999-10-19 US disclosed
EP-0729956-A1 Benzothiophene compounds, intermediates, compositions, and methods ELI LILLY AND COMPANY (US) 1996-09-04 EP disclosed
US-5492922-A PREVENTING RESTENOSIS ELI LILLY AND COMPANY (US) 1996-02-20 US disclosed
US-5488058-A UROGENITAL DISORDERS OR OSTEOPOROSIS ELI LILLY AND COMPANY (US) 1996-01-30 US disclosed