SCHEMBL6550685

SCHEMBL6550685

Cc1ccc2ccc(C)cc2c1.Cc1ccc2cccc(C)c2c1

nearest known ligand 0.88

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 9/20 0.88
CYP1A2 P05177 8/20 0.88
TDP1 Q9NUW8 2/20 0.58
ALDH1A1 P00352 6/20 0.55
HPGD P15428 3/20 0.55
HSD17B10 Q99714 3/20 0.55
KDM4E B2RXH2 1/20 0.42
LMNA P02545 1/20 0.42
GAA P10253 1/20 0.42
TSHR P16473 2/20 0.42
CYP3A4 P08684 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
MAOA P21397 2/20 0.41
ACHE P22303 1/20 0.39
THRB P10828 1/20 0.37
MAOB P27338 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL597735 0.94 CYP1A2 (1.00) CYP2A6CYP1A2TDP1ALDH1A1HPGD
SCHEMBL29470563 0.94 CYP1A2 (1.00) CYP2A6CYP1A2TDP1ALDH1A1HPGD
Ammonia Solution, Strong SCHEMBL27919256 0.91 CYP1A2 (0.95) CYP2A6CYP1A2TDP1ALDH1A1HPGD
SCHEMBL588278 0.90 CYP1A2 (0.84) CYP2A6CYP1A2TDP1ALDH1A1HPGD
O-Xylene SCHEMBL7555306 0.89 CYP2A6 (0.91) CYP2A6CYP1A2TDP1ALDH1A1HPGD
SCHEMBL27905506 0.86 CYP1A2 (0.70) CYP2A6CYP1A2TDP1ALDH1A1HPGD
SCHEMBL6764197 0.86 CYP1A2 (0.70) CYP2A6CYP1A2TDP1ALDH1A1HPGD
SCHEMBL9764735 0.86 CYP1A2 (0.70) CYP2A6CYP1A2TDP1ALDH1A1HPGD
SCHEMBL5494664 0.86 CYP2A6 (0.70) CYP2A6CYP1A2TDP1ALDH1A1HPGD
SCHEMBL28887801 0.82 CYP1A2 (0.78) CYP2A6CYP1A2TDP1ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1483379-A2 USE OF XYLENE MONOOXYGENASE FOR THE OXIDATION OF SUBSTITUTED POLYCYCLIC AROMATIC COMPOUNDS E.I. DU PONT DE NEMOURS AND COMPANY (US) 2004-12-08 EP claimed
WO-2003068735-A2 USE OF XYLENE MONOOXYGENASE FOR THE OXIDATION OF SUBSTITUTED POLYCYCLIC AROMATIC COMPOUNDS E.I. DU PONT DE NEMOURS AND COMPANY (US) 2003-08-21 WO claimed
US-20030077768-A1 Use of xylene monooxygenase for the oxidation of substituted polycyclic aromatic compounds E.I. DU PONT DE NEMOURS AND COMPANY 2003-04-24 US claimed