Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LNPEP | Q9UIQ6 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NAAA | Q02083 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | SCN1A | P35498 | 1/20 | 0.34 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.34 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23465603 | 0.90 | NPC1 (0.38) | EPHX1ALDH1A1KDM4ELMNA | |
| SCHEMBL21325445 | 0.90 | NPC1 (0.38) | EPHX1ALDH1A1KDM4ELMNA | |
| SCHEMBL721104 | 0.81 | SLC1A3 (0.44) | EPHX1SLC1A3SLC1A2SLC1A1ALDH1A1 | |
| SCHEMBL25662304 | 0.79 | GRIK1 (0.44) | SLC1A3SLC1A2SLC1A1ALDH1A1LNPEP | |
| SCHEMBL3447889 | 0.79 | GRIK1 (0.44) | SLC1A3SLC1A2SLC1A1ALDH1A1LNPEP | |
| SCHEMBL724270 | 0.79 | GRIK1 (0.44) | SLC1A3SLC1A2SLC1A1ALDH1A1LNPEP | |
| SCHEMBL27993530 | 0.77 | ALDH1A1 (0.35) | EPHX1ALDH1A1KDM4ENAAACYP1A2 | |
| SCHEMBL25356877 | 0.77 | GRIK1 (0.42) | SLC1A3SLC1A2SLC1A1ALDH1A1CYP1A2 | |
| SCHEMBL25356880 | 0.77 | GRIK1 (0.42) | SLC1A3SLC1A2SLC1A1ALDH1A1CYP1A2 | |
| SCHEMBL24954297 | 0.74 | GABRP (0.32) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1043376-B1 | Use of anionic or cationic plasticizers with sulfonated polyesters in hot melt formulations | NAT STARCH CHEM INVEST (US) | 2004-12-08 | — | — | EP | claimed |
| EP-0364331-B1 | Water-dissipatable polyester resins and coatings prepared therefrom | EASTMAN KODAK CO (US) | 1994-06-08 | — | — | EP | claimed |