SCHEMBL6551606

SCHEMBL6551606

Cc1cc(C)c(C=O)c(C)c1C=O

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.38
MAPT P10636 2/20 0.38
ALDH1A1 P00352 4/20 0.35
TSHR P16473 1/20 0.35
ERN1 O75460 4/20 0.34
USP2 O75604 2/20 0.32
ALB P02768 1/20 0.32
GRIA1 P42261 1/20 0.32
GRIA2 P42262 1/20 0.32
GRIA3 P42263 1/20 0.32
GRIA4 P48058 1/20 0.32
CYP2A6 P11509 2/20 0.32
BCL2 P10415 2/20 0.32
MCL1 Q07820 2/20 0.32
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
TDP1 Q9NUW8 2/20 0.32
HPGD P15428 2/20 0.32
HSD17B10 Q99714 2/20 0.32
LMNA P02545 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1313257 0.89 CYP3A4 (0.35) CYP3A4MAPTALDH1A1TSHRERN1
SCHEMBL19825897 0.83 ERN1 (0.35) CYP3A4MAPTERN1HPGDHSD17B10
SCHEMBL363023 0.83 CYP3A4 (0.44) CYP3A4MAPTALDH1A1ERN1USP2
SCHEMBL29516419 0.83 CYP3A4 (0.44) CYP3A4MAPTALDH1A1ERN1USP2
SCHEMBL1311847 0.82 CYP3A4 (0.38) CYP3A4MAPTALDH1A1TSHRERN1
SCHEMBL30631691 0.81 HPGD (0.40) CYP3A4MAPTALDH1A1USP2BCL2
SCHEMBL10383900 0.79 ALDH1A1 (0.39) CYP3A4MAPTALDH1A1TSHRERN1
SCHEMBL18077441 0.79 HPGD (0.39) CYP3A4MAPTALDH1A1USP2MEN1
SCHEMBL19817104 0.79 ALDH1A1 (0.36) CYP3A4MAPTALDH1A1TSHRERN1
SCHEMBL10504348 0.79 AKR1B1 (0.41) CYP3A4MAPTALDH1A1TSHRERN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1386603-A1 Use of diamines having at least one quaternised group and dialdehydes for dyeing keratin fibres L'OREAL (FR) 2004-02-04 EP claimed
EP-1386603-A1 Use of diamines having at least one quaternised group and dialdehydes for dyeing keratin fibres L'OREAL (FR) 2004-02-04 EP disclosed
US-6355826-B1 HALOMETHYLATION AN AROMATIC ALDEHYDE COMPOUND AND SALT FORMATION THE GOODYEAR TIRE & RUBBER COMPANY 2002-03-12 US disclosed
US-6252009-B1 CROSSLINKING ACRYLONITRILE WITH DIISOCYANATE THE GOODYEAR TIRE & RUBBER COMPANY 2001-06-26 US disclosed
EP-0903338-A2 Synthesis of stable nitrile oxide compounds THE GOODYEAR TIRE & RUBBER COMPANY (US) 1999-03-24 EP disclosed