Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.52 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16546679 | 0.88 | ALDH1A1 (0.55) | ALDH1A1KDM4EMAPTPOLBKCNH2 | |
| SCHEMBL5676073 | 0.85 | ALDH1A1 (0.52) | ALDH1A1KDM4EMAPTPOLBKCNH2 | |
| SCHEMBL19954286 | 0.81 | DRD2 (0.55) | ALDH1A1KDM4EMAPTPOLBKCNH2 | |
| SCHEMBL30416085 | 0.81 | DRD2 (0.55) | ALDH1A1KDM4EMAPTPOLBKCNH2 | |
| SCHEMBL3867807 | 0.79 | KDM4E (0.64) | ALDH1A1KDM4EMAPTPOLBKCNH2 | |
| SCHEMBL7297746 | 0.79 | POLB (0.59) | ALDH1A1KDM4EMAPTPOLBKCNH2 | |
| SCHEMBL13711971 | 0.79 | KCNH2 (0.71) | ALDH1A1POLBKCNH2HTR1A | |
| SCHEMBL5677569 | 0.78 | ALDH1A1 (0.49) | ALDH1A1KDM4EMAPTPOLBKCNH2 | |
| SCHEMBL15800694 | 0.78 | PLD1 (0.73) | ALDH1A1KDM4EMAPTPOLBKCNH2 | |
| SCHEMBL21353591 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1483258-A1 | BENZIMIDAZOLE-DERIVATIVES FOR THE TREATMENT OF SEXUAL DYSFUNCTION | Abbott Laboratories (US) | 2004-12-08 | — | — | EP | disclosed |
| EP-1373220-A1 | BENZIMIDAZOLES THAT ARE USEFUL IN TREATING SEXUAL DYSFUNCTION | ABBOTT LABORATORIES (US) | 2004-01-02 | — | — | EP | disclosed |
| WO-2003076431-A1 | BENZIMIDAZOLE-DERIVATIVES FOR THE TREATMENT OF SEXUAL DYSFUNCTION | ABBOTT LABORATORIES (US) | 2003-09-18 | — | — | WO | disclosed |
| WO-2002088093-A1 | BENZIMIDAZOLES THAT ARE USEFUL IN TREATING SEXUAL DYSFUNCTION | ABBOTT LABORATORIES (US) | 2002-11-07 | — | — | WO | disclosed |