Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | APP | P05067 | 2/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.36 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.36 |
| ▸ | GHSR | Q92847 | 4/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5679194 | 1.00 | MEN1 (0.37) | MEN1KMT2AAPPFFAR1KCNE1 | |
| SCHEMBL5209967 | 0.95 | MEN1 (0.36) | MEN1KMT2AAPPFFAR1KCNE1 | |
| SCHEMBL3290077 | 0.95 | MEN1 (0.36) | MEN1KMT2AAPPFFAR1KCNE1 | |
| SCHEMBL3287419 | 0.92 | MEN1 (0.39) | MEN1KMT2AAPPFFAR1GHSR | |
| SCHEMBL5263054 | 0.92 | MEN1 (0.39) | MEN1KMT2AAPPFFAR1GHSR | |
| SCHEMBL3142761 | 0.91 | MEN1 (0.40) | MEN1KMT2AAPPFFAR1KCNE1 | |
| SCHEMBL3142767 | 0.91 | MEN1 (0.40) | MEN1KMT2AAPPFFAR1KCNE1 | |
| SCHEMBL5203422 | 0.91 | MEN1 (0.40) | MEN1KMT2AAPPFFAR1KCNE1 | |
| SCHEMBL5207827 | 0.90 | MGLL (0.39) | MEN1KMT2AHDAC3HDAC1HDAC2 | |
| SCHEMBL5207830 | 0.90 | MGLL (0.39) | MEN1KMT2AHDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1292572-B1 | PROPANOLAMINOTETRALINES, PREPARATION THEREOF AND COMPOSITIONS CONTAINING SAME | SANOFI SYNTHELABO (FR) | 2004-02-18 | — | — | EP | disclosed |
| EP-1292572-A1 | PROPANOLAMINOTETRALINES, PREPARATION THEREOF AND COMPOSITIONS CONTAINING SAME | SANOFI-SYNTHELABO (FR) | 2003-03-19 | — | — | EP | disclosed |
| WO-2001094307-A1 | PROPANOLAMINOTETRALINES, PREPARATION THEREOF AND COMPOSITIONS CONTAINING SAME | SANOFI-SYNTHELABO (FR) | 2001-12-13 | — | — | WO | disclosed |