Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.37 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.37 |
| ▸ | GHSR | Q92847 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3142761 | 1.00 | MEN1 (0.40) | MEN1KMT2ACYP19A1FFAR1APP | |
| SCHEMBL5203422 | 1.00 | MEN1 (0.40) | MEN1KMT2ACYP19A1FFAR1APP | |
| SCHEMBL3287419 | 0.92 | MEN1 (0.39) | MEN1KMT2AFFAR1APPTDP1 | |
| SCHEMBL3289538 | 0.92 | KEAP1 (0.40) | MEN1KMT2AFFAR1APPGHSR | |
| SCHEMBL5263054 | 0.92 | MEN1 (0.39) | MEN1KMT2AFFAR1APPTDP1 | |
| SCHEMBL5264076 | 0.92 | KEAP1 (0.40) | MEN1KMT2AFFAR1APPGHSR | |
| SCHEMBL6552283 | 0.91 | MEN1 (0.37) | MEN1KMT2AFFAR1APPTDP1 | |
| SCHEMBL5679194 | 0.91 | MEN1 (0.37) | MEN1KMT2AFFAR1APPTDP1 | |
| SCHEMBL5205302 | 0.90 | ALDH1A1 (0.40) | MEN1KMT2ACYP19A1FFAR1TDP1 | |
| SCHEMBL5205310 | 0.90 | ALDH1A1 (0.40) | MEN1KMT2ACYP19A1FFAR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7718646-B2 | Cyclohexyl(alkyl)propanolamines, preparation method and pharmaceutical compositions containing same | SANOFI-AVENTIS (FR) | 2010-05-18 | — | — | US | disclosed |
| US-20100075986-A1 | Oxophenyl-Cyclohexyl-Propanolamine Derivatives, Production And Use Thereof In Therapeutics | SANOFI-AVENTIS (FR) | 2010-03-25 | — | — | US | disclosed |
| EP-1453796-B1 | PROPANOLAMINOMETHYLTETRALINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | SANOFI AVENTIS (FR) | 2010-03-03 | — | — | EP | disclosed |
| US-7625929-B2 | Oxophenyl-cyclohexyl-propanolamine derivatives, production and use thereof in therapeutics | SANOFI-AVENTIS (FR) | 2009-12-01 | — | — | US | disclosed |
| US-7453010-B2 | Phenylcyclohexylpropanolamine derivatives, preparation and therapeutic application thereof | SANOFI AVENTIS (FR) | 2008-11-18 | — | — | US | disclosed |
| US-20080261949-A1 | ethyl 4-[4-(2-hydroxy-3-(4-hydroxy-3-(methylsulphonylamino)phenoxy)propylamino)cyclohexyl]benzoic acid; beta-3 adrenergic receptor agonist; tocolytics; delaying preterm birth; antidiabetic; obesity; oxyalkylation of the phenyl(alkyl)cyclohexyl(alkyl)amine with a glycidyl ether | SANOFI-AVENTIS (FR) | 2008-10-23 | — | — | US | disclosed |
| US-7419974-B2 | Cyclohexyl(alkyl)propanolamines, preparation method and pharmaceutical compositions containing same | SANOFI-AVENTIS (FR) | 2008-09-02 | — | — | US | disclosed |
| US-7388031-B2 | Cyclohexyl(alkyl)-propanolamines, preparation method and pharmaceutical compositions containing same | SANOFI-AVENTIS (FR) | 2008-06-17 | — | — | US | disclosed |
| EP-1511722-B1 | PHENYLCYCLOHEXYLPROPANOLAMINE DERIVATIVES, PREPARATION AND THERAPEUTIC APPLICATION THEREOF | SANOFI AVENTIS (FR) | 2007-10-03 | — | — | EP | disclosed |
| EP-1341753-B1 | CYCLOHEXYL(ALKYL)-PROPANOLAMINES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI AVENTIS (FR) | 2007-09-26 | — | — | EP | disclosed |
| US-20050054641-A1 | Propanolaminomethyltetralines, their preparation and pharmaceutical composition comprising same | SANOFI-AVENTIS (FR) | 2005-03-10 | — | — | US | disclosed |
| EP-1511728-A2 | OXOPHENYL-CYCLOHEXYL-PROPANOLAMINE DERIVATIVES, PRODUCTION AND USE THEREOF IN THERAPEUTICS | Sanofi-Aventis (FR) | 2005-03-09 | — | — | EP | disclosed |
| EP-1511722-A1 | PHENYLCYCLOHEXYLPROPANOLAMINE DERIVATIVES, PREPARATION AND THERAPEUTIC APPLICATION THEREOF | Sanofi-Aventis (FR) | 2005-03-09 | — | — | EP | disclosed |
| EP-1453796-A2 | PROPANOLAMINOMETHYLTETRALINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | Sanofi-Aventis (FR) | 2004-09-08 | — | — | EP | disclosed |
| US-20040053916-A1 | Cyclohexyl(alkyl)-propanolamines, preparation method and pharmaceutical compositions containing same | SANOFI (FR) | 2004-03-18 | — | — | US | disclosed |
| WO-2003099772-A1 | PHENYLCYCLOHEXYLPROPANOLAMINE DERIVATIVES, PREPARATION AND THERAPEUTIC APPLICATION THEREOF | SANOFI-AVENTIS (FR) | 2003-12-04 | — | — | WO | disclosed |
| WO-2003099819-A2 | OXOPHENYL-CYCLOHEXYL-PROPANOLAMINE DERIVATIVES, PRODUCTION AND USE THEREOF IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2003-12-04 | — | — | WO | disclosed |
| EP-1341753-A1 | CYCLOHEXYL(ALKYL)-PROPANOLAMINES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Sanofi-Aventis (FR) | 2003-09-10 | — | — | EP | disclosed |
| WO-2003048117-A2 | PROPANOLAMINOMETHYLTETRALINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | SANOFI-SYNTHELABO (FR) | 2003-06-12 | — | — | WO | disclosed |
| WO-2002044139-A1 | CYCLOHEXYL(ALKYL)-PROPANOLAMINES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI-SYNTHELABO (FR) | 2002-06-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080261949-A1 | ethyl 4-[4-(2-hydroxy-3-(4-hydroxy-3-(methylsulphonylamino)phenoxy)propylamino)cyclohexyl]benzoic acid; beta-3 adrenergic receptor agonist; tocolytics; delaying preterm birth; antidiabetic; obesity; oxyalkylation of the phenyl(alkyl)cyclohexyl(alkyl)amine with a glycidyl ether | ADRB3, FFAR3, ADRB2 | MEN1 4724/4885KMT2A 4099/4885CYP19A1 1040/4885 |
| US-20100075986-A1 | Oxophenyl-Cyclohexyl-Propanolamine Derivatives, Production And Use Thereof In Therapeutics | HRH4, HRH3, AOC3 | MEN1 1003/4885KMT2A 2359/4885CYP19A1 1590/4885 |
| US-20040053916-A1 | Cyclohexyl(alkyl)-propanolamines, preparation method and pharmaceutical compositions containing same | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, ADRA2C, ADRA1A | MEN1 1129/4885KMT2A 2995/4885CYP19A1 506/4885 |
| US-20050054641-A1 | Propanolaminomethyltetralines, their preparation and pharmaceutical composition comprising same | ALK, CHRM4, CHRM2 | MEN1 1820/4885KMT2A 3125/4885CYP19A1 1098/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.