Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 5/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29288548 | 0.92 | SLC6A4 (0.43) | SLC6A4POLBHTTNPSR1OPRM1 | |
| SCHEMBL20249605 | 0.80 | SLC6A4 (0.40) | SLC6A4POLBHTTNPSR1OPRM1 | |
| SCHEMBL28487473 | 0.78 | SLC6A4 (0.46) | SLC6A4POLBHTTNPSR1OPRM1 | |
| SCHEMBL31560810 | 0.74 | ELOVL1 (0.44) | SLC6A4POLBMEN1KMT2ATSHR | |
| SCHEMBL20249699 | 0.74 | ELOVL1 (0.44) | SLC6A4POLBMEN1KMT2ATSHR | |
| SCHEMBL11048173 | 0.72 | SLC6A4 (0.46) | SLC6A4POLBHTTNPSR1OPRM1 | |
| SCHEMBL28426673 | 0.72 | AKR1C1 (0.53) | HTTNPSR1MEN1KMT2ALMNA | |
| SCHEMBL16833940 | 0.71 | SLC6A4 (0.44) | SLC6A4POLBHTTNPSR1MEN1 | |
| SCHEMBL20242106 | 0.70 | SLC6A4 (0.54) | SLC6A4POLBHTTNPSR1OPRM1 | |
| SCHEMBL28149790 | 0.69 | AKR1C1 (0.46) | SLC6A4POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1482921-A1 | METHODS OF TREATING ATTENTION DEFICIT/HYPERACTIVITY DISORDER (ADHD) | Cypress Bioscience, Inc. (US) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003068211-A1 | METHODS OF TREATING ATTENTION DEFICIT/HYPERACTIVITY DISORDER (ADHD) | CYPRESS BIOSCIENCE, INC. (US) | 2003-08-21 | — | — | WO | disclosed |