Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 2/20 | 0.64 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | HBB | P68871 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridine SCHEMBL1830428 | 0.90 | CHRM5 (0.80) | CHKACHRM5SMN1; SMN2MAPTKMT2A | |
| SCHEMBL6199563 | 0.90 | CHRM5 (0.80) | CHKACHRM5SMN1; SMN2MAPTKMT2A | |
| Benzene SCHEMBL28113160 | 0.84 | CHRM5 (0.89) | CHKACHRM5SMN1; SMN2MAPTKMT2A | |
| Methyl Alcohol SCHEMBL27883706 | 0.84 | ALDH1A1 (0.59) | CHKACHRM5SMN1; SMN2MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL6427969 | 0.84 | ALDH1A1 (0.59) | CHKACHRM5SMN1; SMN2MAPTKMT2A | |
| Methyl Alcohol SCHEMBL28992242 | 0.84 | ALDH1A1 (0.59) | CHKACHRM5SMN1; SMN2MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL30327422 | 0.84 | ALDH1A1 (0.59) | CHKACHRM5SMN1; SMN2MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL15546092 | 0.84 | ALDH1A1 (0.59) | CHKACHRM5SMN1; SMN2MAPTKMT2A | |
| SCHEMBL16187039 | 0.84 | — | — | |
| SCHEMBL8277 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102603659-A | Preparation method of 1-substituted-4-bromo-1H-1,2,3-triazole-5-carboxylic acid | SUZHOU ABA CHEMICAL CO LTD | 2012-07-25 | — | — | CN | claimed |
| CN-102408385-A | Preparation method of 2-substituted-2H-1, 2, 3-triazole derivative | SUZHOU ABA CHEMICALS CO LTD | 2012-04-11 | — | — | CN | claimed |
| JP-54090174-A | — | — | None | — | — | JP | disclosed |
| US-10507209-B2 | Quinazoline derivatives substituted by aniline, preparation method and use thereof | XUANZHU PHARMA CO, LTD. (CN) | 2019-12-17 | — | — | US | disclosed |
| US-20170333433-A1 | QUINAZOLINE DERIVATIVES SUBSTITUTED BY ANILINE, PREPARATION METHOD AND USE THEREOF | XUANZHU PHARMA CO, LTD. (CN) | 2017-11-23 | — | — | US | disclosed |
| US-20170304305-A1 | QUINAZOLINE DERIVATIVES SUBSTITUTED BY ANILINE, PREPARATION METHOD AND USE THEREOF | XUANZHU PHARMA CO LTD (CN) | 2017-10-26 | — | — | US | disclosed |
| US-9730934-B2 | Quinazoline derivatives substituted by aniline, preparation method and use thereof | Xuanzhu Pharma Co., Ltd. (CN) | 2017-08-15 | — | — | US | disclosed |
| EP-2612860-B1 | QUINAZOLINE DERIVATIVES SUBSTITUTED BY ANILINE, PREPARATION METHOD AND USE THEREOF | XUANZHU PHARMA CO LTD (CN) | 2017-03-15 | — | — | EP | disclosed |
| US-20130184297-A1 | QUINAZOLINE DERIVATIVES SUBSTITUTED BY ANILINE, PREPARATION METHOD AND USE THEREOF | Xuanzhu Pharma Co., Ltd. (CN) | 2013-07-18 | — | — | US | disclosed |
| EP-2612860-A1 | QUINAZOLINE DERIVATIVES SUBSTITUTED BY ANILINE, PREPARATION METHOD AND USE THEREOF | Xuanzhu Pharma Co., Ltd. (CN) | 2013-07-10 | — | — | EP | disclosed |
| CN-101243053-B | N-acylamino acid derivatives, process for their preparation, pharmaceutical compositions and their use as antiallergic, antiinflammatory and hypolipidemic agents | OTKRYTOE AKTSIONERNOE OBSCHEST | 2012-08-08 | — | — | CN | disclosed |
| EP-0112164-A2 | Cephem compounds, and their production, and medicaments containing them | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1984-06-27 | — | — | EP | disclosed |
| EP-0100250-A2 | Methylflavone derivatives | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1984-02-08 | — | — | EP | disclosed |
| EP-0077534-A2 | Benzamide derivatives, a process for preparing the same, and pharmaceutical compositions containing the same | Chugai Seiyaku Kabushiki Kaisha (JP) | 1983-04-27 | — | — | EP | disclosed |
| US-4358408-A | INSECTICIDES, MITICIDES, NEMATOCIDES | SCHERING AG (DE) | 1982-11-09 | — | — | US | disclosed |
| US-4353802-A | Semipermeable composite membrane | TEIJIN LIMITED (JP) | 1982-10-12 | — | — | US | disclosed |
| EP-0002821-B1 | CYCLIC PHOSPHITES AND ORGANIC MATERIAL STABILIZED BY THEM | CIBA-GEIGY AG (CH) | 1982-06-23 | — | — | EP | disclosed |
| EP-0010425-A1 | Semipermeable composite membrane and the preparation thereof | TEIJIN LIMITED (JP) | 1980-04-30 | — | — | EP | disclosed |
| JP-S5490174-A | NOVEL INDOMETHACIN DERIVATIVES AND THEIR PREPARATION | KANEBO LTD | 1979-07-17 | — | — | JP | disclosed |
| EP-0002821-A1 | Cyclic phosphites and organic material stabilized by them | CIBA-GEIGY AG (CH) | 1979-07-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170304305-A1 | QUINAZOLINE DERIVATIVES SUBSTITUTED BY ANILINE, PREPARATION METHOD AND USE THEREOF | NQO2, CHRM1, CHRM2 | CHKA 3027/4885CHRM5 16/4885SMN1; SMN2 4480/4885 |
| US-20170333433-A1 | QUINAZOLINE DERIVATIVES SUBSTITUTED BY ANILINE, PREPARATION METHOD AND USE THEREOF | NQO2, CHRM1, CHRM2 | CHKA 3027/4885CHRM5 16/4885SMN1; SMN2 4480/4885 |
| US-10507209-B2 | Quinazoline derivatives substituted by aniline, preparation method and use thereof | NQO2, CHRM1, CHRM2 | CHKA 3027/4885CHRM5 16/4885SMN1; SMN2 4480/4885 |
| US-20130184297-A1 | QUINAZOLINE DERIVATIVES SUBSTITUTED BY ANILINE, PREPARATION METHOD AND USE THEREOF | NQO2, CHRM1, CHRM2 | CHKA 3027/4885CHRM5 16/4885SMN1; SMN2 4480/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.