SCHEMBL6553501

SCHEMBL6553501

Fc1cc(F)c(F)c(Br)c1F.[MgH2]

nearest known ligand 0.36

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CA1 P00915 3/20 0.36
CA2 P00918 3/20 0.36
CA4 P22748 2/20 0.36
CA12 O43570 1/20 0.36
CA7 P43166 1/20 0.36
CA13 Q8N1Q1 1/20 0.36
CES2 O00748 1/20 0.33
CES1 P23141 1/20 0.33
KDM1A O60341 2/20 0.31
KDM1B Q8NB78 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL10982440 0.97 CA1 (0.35) CA1CA2CA4CA12CA7
SCHEMBL439846 0.97 CA1 (0.38) CA1CA2CA4CA12CA7
Ethylene SCHEMBL27505929 0.90 CA1 (0.35) CA1CA2CA4CA12CA7
Bromide SCHEMBL10982443 0.90 CA1 (0.35) CA1CA2CA4CA12CA7
Cyanide SCHEMBL21633856 0.88 CA1 (0.33) CA1CA2CA4CA12CA7
SCHEMBL28420644 0.84 AKR1B1 (0.35) CA1CA2CA4CA12CA7
SCHEMBL4601309 0.81 CA12 (0.33) CA1CA2CA12CA7CA13
Acetonitrile SCHEMBL28945834 0.81 CA1 (0.30) CA1CA2CA4CA12CA7
Phosphoric Acid SCHEMBL28983528 0.81 CA1 (0.39) CA1CA2CA4CA12CA7
SCHEMBL28498845 0.79 CA1 (0.32) CA1CA2CA4CA12CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0995753-B1 Method for manufacturing fluoroaryl magnesium halide NIPPON CATALYTIC CHEM IND (JP) 2004-02-18 EP disclosed
US-6235222-B1 REACTING, IN SOLVENT CONTAINING CHAIN ETHER SOLVENT, HYDROCARBON MAGNESIUM HALIDE WITH FLUOROARYL HALIDE NIPPON SHOKUBAI CO., LTD. (JP) 2001-05-22 US disclosed
EP-0995753-A2 Method for manufacturing fluoroaryl magnesium halide Nippon Shokubai Co., Ltd. (JP) 2000-04-26 EP disclosed