Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 11/20 | 0.59 |
| ▸ | ADORA2A | P29274 | 8/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.47 |
| ▸ | GPR183 | P32249 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6553611 | 1.00 | ADORA2B (0.59) | ADORA2BADORA2AADORA1ADORA3GPR183 | |
| SCHEMBL6554077 | 0.90 | ADORA2B (0.72) | ADORA2BADORA2AADORA1ADORA3PTPN1 | |
| SCHEMBL6554070 | 0.90 | ADORA2B (0.72) | ADORA2BADORA2AADORA1ADORA3PTPN1 | |
| SCHEMBL6555301 | 0.89 | ADORA2B (0.60) | ADORA2BADORA2AADORA1ADORA3PTPN1 | |
| SCHEMBL6555310 | 0.89 | ADORA2B (0.60) | ADORA2BADORA2AADORA1ADORA3PTPN1 | |
| SCHEMBL6553578 | 0.85 | ADORA2B (0.60) | ADORA2BADORA2AADORA1ADORA3PTPN1 | |
| SCHEMBL6553587 | 0.85 | ADORA2B (0.60) | ADORA2BADORA2AADORA1ADORA3PTPN1 | |
| SCHEMBL6554030 | 0.84 | ADORA2B (0.43) | ADORA2BADORA2AADORA1ADORA3GPR183 | |
| SCHEMBL6555284 | 0.84 | ADORA2B (0.56) | ADORA2BADORA2AADORA1ADORA3GPR183 | |
| SCHEMBL6555287 | 0.84 | ADORA2B (0.56) | ADORA2BADORA2AADORA1ADORA3GPR183 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1104422-B1 | PHENYL XANTHINE DERIVATIVES | GLAXO GROUP LTD (GB) | 2004-02-18 | — | — | EP | disclosed |