Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 14/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.31 |
| ▸ | MERTK | Q12866 | 1/20 | 0.31 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13053078 | 0.80 | CYP11B1 (0.42) | CYP11B1CYP11B2ENPP2SIRT2 | |
| SCHEMBL27975355 | 0.79 | CYP11B1 (0.49) | CYP11B1CYP11B2ENPP2SIRT2CYP19A1 | |
| SCHEMBL2918068 | 0.77 | CYP19A1 (0.39) | CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL2915674 | 0.74 | CYP3A4 (0.41) | CYP11B1CYP11B2ENPP2CYP19A1 | |
| SCHEMBL1807602 | 0.74 | CYP11B1 (0.43) | CYP11B1CYP11B2ENPP2SIRT2CYP19A1 | |
| SCHEMBL9547341 | 0.73 | CYP11B1 (0.39) | CYP11B1CYP11B2ENPP2SIRT2CYP19A1 | |
| SCHEMBL9547333 | 0.73 | CYP11B1 (0.39) | CYP11B1CYP11B2ENPP2SIRT2CYP19A1 | |
| SCHEMBL1097106 | 0.72 | CYP11B1 (0.36) | CYP11B1CYP11B2ENPP2SIRT2 | |
| SCHEMBL7714934 | 0.72 | CYP11B1 (0.34) | CYP11B1CYP11B2ENPP2SIRT2 | |
| SCHEMBL7710617 | 0.72 | CYP11B1 (0.34) | CYP11B1CYP11B2SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708179-B1 | Glucagon-like insulinotropic peptide analogs, compositions, and methods of use | LILLY CO ELI (US) | 2004-12-22 | — | — | EP | disclosed |
| EP-1227151-A1 | Glucagon-like insulinotropic peptide analogs, compositions, and methods of use | ELI LILLY AND COMPANY (US) | 2002-07-31 | — | — | EP | disclosed |
| US-5512549-A | ANTIDIABETIC AGENTS | ELI LILLY AND COMPANY (US) | 1996-04-30 | — | — | US | disclosed |
| EP-0708179-A2 | Glucagon-like insulinotropic peptide analogs, compositions, and methods of use | ELI LILLY AND COMPANY (US) | 1996-04-24 | — | — | EP | disclosed |