Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 5/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | EGLN2 | Q96KS0 | 4/20 | 0.31 |
| ▸ | KDM1A | O60341 | 2/20 | 0.31 |
| ▸ | NSD2 | O96028 | 1/20 | 0.31 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.31 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.31 |
| ▸ | MLNR | O43193 | 1/20 | 0.30 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.30 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.30 |
| ▸ | CCKBR | P32239 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7710617 | 0.87 | CYP11B1 (0.34) | CYP11B1CYP11B2S1PR3SIRT2S1PR1 | |
| SCHEMBL7984249 | 0.80 | S1PR3 (0.38) | S1PR3S1PR1 | |
| SCHEMBL7713179 | 0.78 | S1PR3 (0.41) | S1PR3S1PR1EGLN2NSD2 | |
| SCHEMBL7677947 | 0.73 | SIRT2 (0.39) | CYP11B1CYP11B2SIRT2EGLN2NSD2 | |
| SCHEMBL6553669 | 0.72 | CYP11B1 (0.39) | CYP11B1CYP11B2SIRT2ENPP2 | |
| SCHEMBL7191177 | 0.72 | S1PR3 (0.35) | CYP11B1CYP11B2S1PR3S1PR1 | |
| SCHEMBL7713123 | 0.72 | KCNQ3 (0.38) | CYP11B1CYP11B2S1PR3S1PR1EGLN2 | |
| SCHEMBL2918068 | 0.70 | CYP19A1 (0.39) | CYP11B1CYP11B2 | |
| SCHEMBL7220893 | 0.69 | CYP11B1 (0.44) | CYP11B1CYP11B2 | |
| SCHEMBL2915674 | 0.68 | CYP3A4 (0.41) | CYP11B1CYP11B2ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441017-B1 | Inhibitors of prenyl-protein transferase | MERCK & CO., INC. | 2002-08-27 | — | — | US | disclosed |
| EP-1214326-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001018006-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-03-15 | — | — | WO | disclosed |