Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6554724 | 0.87 | NPC1 (0.39) | NPC1RAB9APGRPNMTHTR7 | |
| Hydrochloric Acid SCHEMBL8510219 | 0.87 | NPC1 (0.32) | NPC1RAB9APGR | |
| Hydrochloric Acid SCHEMBL7101940 | 0.84 | NPC1 (0.35) | NPC1RAB9APGRPNMTHTR7 | |
| Hydrochloric Acid SCHEMBL10320383 | 0.83 | PNMT (0.41) | NPC1RAB9APNMTHTR7HTR2B | |
| Hydrochloric Acid SCHEMBL6554860 | 0.82 | NPC1 (0.34) | NPC1RAB9APGRPNMTHTR7 | |
| Hydrochloric Acid SCHEMBL1235559 | 0.81 | NPC1 (0.34) | NPC1RAB9APNMTHTR7HTR2B | |
| Hydrochloric Acid SCHEMBL440209 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL3012217 | 0.78 | NPC1 (0.33) | NPC1RAB9APGRPNMT | |
| Hydrochloric Acid SCHEMBL8509884 | 0.77 | PNMT (0.33) | NPC1RAB9APNMT | |
| Hydrochloric Acid SCHEMBL218253 | 0.77 | NPC1 (0.35) | NPC1RAB9APGRPNMTHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0773237-B1 | Olefin polymerization catalyst system | MITSUI CHEMICALS INC (JP) | 2004-02-18 | — | — | EP | disclosed |
| US-5916982-A | Process for the production of polyolefins | NIPPON OIL CO., LTD. (JP) | 1999-06-29 | — | — | US | disclosed |
| EP-0768320-A1 | Catalyst component and catalyst | NIPPON OIL CO. LTD. (JP) | 1997-04-16 | — | — | EP | disclosed |
| EP-0768319-A1 | Process for the production of polyolefins | NIPPON OIL CO. LTD. (JP) | 1997-04-16 | — | — | EP | disclosed |