Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 12/20 | 0.55 |
| ▸ | ADORA2A | P29274 | 8/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.55 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 3/20 | 0.36 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6554062 | 1.00 | ADORA2B (0.55) | ADORA2BADORA2AADORA3ADORA1PTPN1 | |
| SCHEMBL6553746 | 0.92 | ADORA2B (0.53) | ADORA2BADORA2AADORA3ADORA1PTPN1 | |
| SCHEMBL6553753 | 0.92 | ADORA2B (0.53) | ADORA2BADORA2AADORA3ADORA1PTPN1 | |
| SCHEMBL9156860 | 0.86 | ADORA2B (0.60) | ADORA2BADORA2AADORA3ADORA1PTPN1 | |
| SCHEMBL9156851 | 0.86 | ADORA2B (0.60) | ADORA2BADORA2AADORA3ADORA1PTPN1 | |
| SCHEMBL9156883 | 0.86 | ADORA2B (0.52) | ADORA2BADORA2AADORA3ADORA1PTPN1 | |
| SCHEMBL9156870 | 0.86 | ADORA2B (0.52) | ADORA2BADORA2AADORA3ADORA1PTPN1 | |
| SCHEMBL6555024 | 0.84 | ADORA2B (0.73) | ADORA2BADORA2AADORA3ADORA1KDM4E | |
| SCHEMBL6555021 | 0.84 | ADORA2B (0.73) | ADORA2BADORA2AADORA3ADORA1KDM4E | |
| SCHEMBL27859100 | 0.84 | ADORA2B (0.74) | ADORA2BADORA2AADORA3ADORA1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0639055-A1 | METHODS OF TREATING OBESITY WITH PURINE RELATED COMPOUNDS | THE PENN STATE RESEARCH FOUNDATION (US) | 1995-02-22 | — | — | EP | claimed |
| WO-1993021783-A1 | METHODS OF TREATING OBESITY WITH PURINE RELATED COMPOUNDS | THE PENN STATE RESEARCH FOUNDATION (US) | 1993-11-11 | — | — | WO | claimed |
| US-4879296-A | BLOCKING ADERNOSINE CELL SURFACE EFFECTS | BURROUGHS WELLCOME CO. (US) | 1989-11-07 | — | — | US | claimed |
| EP-0203721-A2 | 8-Phenyl xanthines | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-12-03 | — | — | EP | claimed |
| EP-1104422-B1 | PHENYL XANTHINE DERIVATIVES | GLAXO GROUP LTD (GB) | 2004-02-18 | — | — | EP | disclosed |
| EP-0639055-A1 | METHODS OF TREATING OBESITY WITH PURINE RELATED COMPOUNDS | THE PENN STATE RESEARCH FOUNDATION (US) | 1995-02-22 | — | — | EP | disclosed |
| US-5300298-A | Methods of treating obesity with purine related compounds | THE PENNSYLVANIA RESEARCH CORPORATION (US) | 1994-04-05 | — | — | US | disclosed |
| WO-1993021783-A1 | METHODS OF TREATING OBESITY WITH PURINE RELATED COMPOUNDS | THE PENN STATE RESEARCH FOUNDATION (US) | 1993-11-11 | — | — | WO | disclosed |
| EP-0203721-B1 | 8-PHENYL XANTHINES | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-06-10 | — | — | EP | disclosed |
| US-5017577-A | Using Purine Cinnamic Acids | BURROUGHS WELLCOME CO. (US) | 1991-05-21 | — | — | US | disclosed |
| US-5015647-A | Using Purine Cinnamic Acid Compounds | BURROUGHS WELLCOME CO. (US) | 1991-05-14 | — | — | US | disclosed |
| US-4981857-A | ADENOSINE ANTAGONIST | BURROUGHS WELLCOME CO. (US) | 1991-01-01 | — | — | US | disclosed |
| US-4879296-A | BLOCKING ADERNOSINE CELL SURFACE EFFECTS | BURROUGHS WELLCOME CO. (US) | 1989-11-07 | — | — | US | disclosed |
| EP-0203721-A2 | 8-Phenyl xanthines | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-12-03 | — | — | EP | disclosed |