SCHEMBL6554262

SCHEMBL6554262

Cc1noc(=O)c2ccc(NCC(O)(CC(C)(C)c3cc(F)ccc3O)C(F)(F)F)cc12

nearest known ligand 0.80

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
NR3C1 P04150 20/20 0.80
PGR P06401 10/20 0.80
NR3C2 P08235 7/20 0.73
AR P10275 3/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6554297 0.89 NR3C1 (1.00) NR3C1PGRNR3C2AR
SCHEMBL6078394 0.84 NR3C1 (1.00) NR3C1PGRNR3C2AR
SCHEMBL1931879 0.83 NR3C1 (0.76) NR3C1PGRNR3C2AR
SCHEMBL1931145 0.81 NR3C1 (0.69) NR3C1PGRNR3C2AR
SCHEMBL24252000 0.80 NR3C1 (0.76) NR3C1PGRNR3C2AR
SCHEMBL6555515 0.79 NR3C1 (0.75) NR3C1PGRNR3C2AR
SCHEMBL292625 0.77 NR3C1 (1.00) NR3C1PGRNR3C2AR
SCHEMBL1930910 0.77 NR3C1 (0.52) NR3C1PGRNR3C2AR
SCHEMBL5642001 0.76 NR3C1 (0.85) NR3C1PGRNR3C2AR
SCHEMBL5643172 0.76 NR3C1 (0.85) NR3C1PGRNR3C2AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1133486-B1 NONSTEROIDAL ANTIINFLAMMATORIES SCHERING AG (DE) 2004-12-22 EP claimed
US-6323199-B1 AROMATIC HETEROCYCLIC HYDROXY AMINES OR AMIDES FOR TREATMENT OF INFLAMMATION SCHERING AKTIENGESELLSCHAFT (DE) 2001-11-27 US claimed
EP-1133486-A2 NONSTEROIDAL ANTIINFLAMMATORIES SCHERING AKTIENGESELLSCHAFT (DE) 2001-09-19 EP claimed
WO-2000032584-A2 NONSTEROIDAL ANTIINFLAMMATORIES SCHERING AKTIENGESELLSCHAFT (DE) 2000-06-08 WO claimed
EP-1133486-B1 NONSTEROIDAL ANTIINFLAMMATORIES SCHERING AG (DE) 2004-12-22 EP disclosed
US-6323199-B1 AROMATIC HETEROCYCLIC HYDROXY AMINES OR AMIDES FOR TREATMENT OF INFLAMMATION SCHERING AKTIENGESELLSCHAFT (DE) 2001-11-27 US disclosed
EP-1133486-A2 NONSTEROIDAL ANTIINFLAMMATORIES SCHERING AKTIENGESELLSCHAFT (DE) 2001-09-19 EP disclosed
WO-2000032584-A2 NONSTEROIDAL ANTIINFLAMMATORIES SCHERING AKTIENGESELLSCHAFT (DE) 2000-06-08 WO disclosed