SCHEMBL6554297

SCHEMBL6554297

COc1ccc(F)cc1C(C)(C)CC(O)(CNc1ccc2c(=O)onc(C)c2c1)C(F)(F)F

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
NR3C1 P04150 20/20 1.00
PGR P06401 8/20 1.00
NR3C2 P08235 11/20 0.74
AR P10275 2/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6554262 0.89 NR3C1 (0.80) NR3C1PGRNR3C2AR
SCHEMBL6555515 0.86 NR3C1 (0.75) NR3C1PGRNR3C2AR
SCHEMBL1933203 0.86 NR3C1 (0.75) NR3C1PGRNR3C2AR
SCHEMBL6554366 0.85 NR3C1 (1.00) NR3C1PGRNR3C2AR
SCHEMBL1931013 0.84 NR3C1 (0.73) NR3C1PGRNR3C2AR
SCHEMBL6556479 0.79 NR3C1 (0.71) NR3C1PGRNR3C2AR
SCHEMBL450448 0.79 NR3C1 (0.82) NR3C1PGRNR3C2AR
SCHEMBL1933259 0.78 NR3C1 (0.64) NR3C1PGRNR3C2
SCHEMBL1932374 0.78 NR3C1 (0.64) NR3C1PGRNR3C2
SCHEMBL292542 0.77 NR3C1 (0.82) NR3C1PGRNR3C2AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1133486-B1 NONSTEROIDAL ANTIINFLAMMATORIES SCHERING AG (DE) 2004-12-22 EP claimed
US-6323199-B1 AROMATIC HETEROCYCLIC HYDROXY AMINES OR AMIDES FOR TREATMENT OF INFLAMMATION SCHERING AKTIENGESELLSCHAFT (DE) 2001-11-27 US claimed
EP-1133486-A2 NONSTEROIDAL ANTIINFLAMMATORIES SCHERING AKTIENGESELLSCHAFT (DE) 2001-09-19 EP claimed
WO-2000032584-A2 NONSTEROIDAL ANTIINFLAMMATORIES SCHERING AKTIENGESELLSCHAFT (DE) 2000-06-08 WO claimed
EP-1133486-B1 NONSTEROIDAL ANTIINFLAMMATORIES SCHERING AG (DE) 2004-12-22 EP disclosed
US-6323199-B1 AROMATIC HETEROCYCLIC HYDROXY AMINES OR AMIDES FOR TREATMENT OF INFLAMMATION SCHERING AKTIENGESELLSCHAFT (DE) 2001-11-27 US disclosed
EP-1133486-A2 NONSTEROIDAL ANTIINFLAMMATORIES SCHERING AKTIENGESELLSCHAFT (DE) 2001-09-19 EP disclosed
WO-2000032584-A2 NONSTEROIDAL ANTIINFLAMMATORIES SCHERING AKTIENGESELLSCHAFT (DE) 2000-06-08 WO disclosed