SCHEMBL6554358

SCHEMBL6554358

CC(C)(CC(O)(C(=O)Nc1ccc2c(c1)COC2=O)C(F)(F)F)c1cc(F)ccc1OC(F)F

nearest known ligand 0.83

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
NR3C1 P04150 20/20 0.83
PGR P06401 20/20 0.83
NR3C2 P08235 11/20 0.76
AR P10275 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27482071 0.92 NR3C1 (0.84) NR3C1PGRNR3C2AR
SCHEMBL6585107 0.91 NR3C1 (1.00) NR3C1PGRNR3C2AR
SCHEMBL6556337 0.89 NR3C1 (0.85) NR3C1PGRNR3C2AR
SCHEMBL6554173 0.88 NR3C1 (0.85) NR3C1PGRNR3C2AR
SCHEMBL27481705 0.88 NR3C1 (0.80) NR3C1PGRNR3C2AR
SCHEMBL27480910 0.87 NR3C1 (0.84) NR3C1PGRNR3C2AR
SCHEMBL6554572 0.87 NR3C1 (0.80) NR3C1PGRNR3C2AR
SCHEMBL27498150 0.87 NR3C1 (0.80) NR3C1PGRNR3C2AR
SCHEMBL6555580 0.87 PGR (0.80) NR3C1PGRNR3C2AR
SCHEMBL5642600 0.87 NR3C1 (0.84) NR3C1PGRNR3C2AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1133486-B1 NONSTEROIDAL ANTIINFLAMMATORIES SCHERING AG (DE) 2004-12-22 EP claimed
US-6323199-B1 AROMATIC HETEROCYCLIC HYDROXY AMINES OR AMIDES FOR TREATMENT OF INFLAMMATION SCHERING AKTIENGESELLSCHAFT (DE) 2001-11-27 US claimed
EP-1133486-A2 NONSTEROIDAL ANTIINFLAMMATORIES SCHERING AKTIENGESELLSCHAFT (DE) 2001-09-19 EP claimed
WO-2000032584-A2 NONSTEROIDAL ANTIINFLAMMATORIES SCHERING AKTIENGESELLSCHAFT (DE) 2000-06-08 WO claimed
EP-1133486-B1 NONSTEROIDAL ANTIINFLAMMATORIES SCHERING AG (DE) 2004-12-22 EP disclosed
US-6323199-B1 AROMATIC HETEROCYCLIC HYDROXY AMINES OR AMIDES FOR TREATMENT OF INFLAMMATION SCHERING AKTIENGESELLSCHAFT (DE) 2001-11-27 US disclosed
EP-1133486-A2 NONSTEROIDAL ANTIINFLAMMATORIES SCHERING AKTIENGESELLSCHAFT (DE) 2001-09-19 EP disclosed
WO-2000032584-A2 NONSTEROIDAL ANTIINFLAMMATORIES SCHERING AKTIENGESELLSCHAFT (DE) 2000-06-08 WO disclosed