Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.56 |
| ▸ | CTSK | P43235 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31075491 | 0.88 | CTSS (0.56) | CTSSCTSKMEN1KMT2ACA2 | |
| SCHEMBL6557192 | 0.88 | CTSS (0.56) | CTSSCTSKMEN1KMT2ACA2 | |
| SCHEMBL23975809 | 0.88 | CTSS (0.61) | CTSSCTSKCA2ALDH1A1KDM4E | |
| SCHEMBL7414151 | 0.88 | CTSS (0.61) | CTSSCTSKCA2ALDH1A1KDM4E | |
| SCHEMBL7414154 | 0.88 | CTSS (0.61) | CTSSCTSKCA2ALDH1A1KDM4E | |
| SCHEMBL21585117 | 0.87 | CA2 (0.56) | CTSSCTSKMEN1KMT2ACA2 | |
| SCHEMBL6555039 | 0.87 | HDAC4 (0.55) | CTSSCTSKMEN1KMT2ACA2 | |
| SCHEMBL21585121 | 0.86 | CTSS (0.54) | CTSSCTSKMEN1KMT2ACA2 | |
| SCHEMBL7407818 | 0.86 | CTSS (0.54) | CTSSCTSKMEN1KMT2ACA2 | |
| SCHEMBL21585118 | 0.86 | CA2 (0.55) | CTSSCTSKMEN1KMT2ACA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0797447-B1 | HUMAN CANCER INHIBITORY PENTAPEPTIDE HETEROCYCLIC AND HALOPHENYL AMIDES | UNIV ARIZONA (US) | 2004-03-03 | — | — | EP | disclosed |
| EP-0797447-A4 | HUMAN CANCER INHIBITORY PENTAPEPTIDE HETEROCYCLIC AND HALOPHENYL AMIDES | UNIV ARIZONA (US) | 1999-09-29 | — | — | EP | disclosed |
| EP-0797447-A1 | HUMAN CANCER INHIBITORY PENTAPEPTIDE HETEROCYCLIC AND HALOPHENYL AMIDES | ARIZONA BOARD OF REGENTS (US) | 1997-10-01 | — | — | EP | disclosed |
| US-5663149-A | ANTICARCINOGENIC AGENTS RELATED TO DOLASTATIN | ARIZONA BOARD OF REGENTS ACTING ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 1997-09-02 | — | — | US | disclosed |
| WO-1996018408-A1 | HUMAN CANCER INHIBITORY PENTAPEPTIDE HETEROCYCLIC AND HALOPHENYL AMIDES | ARIZONA BOARD OF REGENTS (US) | 1996-06-20 | — | — | WO | disclosed |