Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 16/20 | 0.45 |
| ▸ | RARG | P13631 | 13/20 | 0.45 |
| ▸ | RARA | P10276 | 6/20 | 0.45 |
| ▸ | RARB | P10826 | 6/20 | 0.45 |
| ▸ | RXRB | P28702 | 4/20 | 0.45 |
| ▸ | RXRG | P48443 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 9/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6555568 | 1.00 | RXRA (0.45) | RXRARARGRARARARBRXRB | |
| SCHEMBL6555573 | 1.00 | RXRA (0.45) | RXRARARGRARARARBRXRB | |
| SCHEMBL8146546 | 0.83 | RXRA (0.68) | RXRARARGRARARARBRXRB | |
| SCHEMBL8145943 | 0.83 | RXRA (0.68) | RXRARARGRARARARBRXRB | |
| SCHEMBL6553357 | 0.82 | NPSR1 (0.43) | MAPTKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL6553355 | 0.82 | NPSR1 (0.43) | MAPTKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL6553808 | 0.81 | RXRA (0.65) | RXRARARGRARARARBRXRB | |
| SCHEMBL6553805 | 0.81 | RXRA (0.65) | RXRARARGRARARARBRXRB | |
| SCHEMBL6553800 | 0.81 | RXRA (0.65) | RXRARARGRARARARBRXRB | |
| SCHEMBL10553569 | 0.79 | KDM4E (0.43) | RXRARARGRARARARBRXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149067-B1 | 7-ARYL-6(Z)HEPTATRIENOIC ACID RETINAMIDES AS APOPTOSIS INDUCING COMPOUNDS AND THEIR USE AS ANTI-CANCER AGENTS | HOFFMANN LA ROCHE (CH) | 2004-02-25 | — | — | EP | disclosed |
| EP-1149067-A1 | 7-ARYL-6(Z)HEPTATRIENOIC ACID RETINAMIDES AS APOPTOSIS INDUCING COMPOUNDS AND THEIR USE AS ANTI-CANCER AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-31 | — | — | EP | disclosed |
| US-6310247-B1 | HAS APOPTOTIC ACTIVITY USEFUL FOR PROPHYLAXIS AND THERAPY OF CANCER | HOFFMANN-LA ROCHE INC. | 2001-10-30 | — | — | US | disclosed |
| WO-2000035856-A1 | 7-ARYL-6(Z)HEPTATRIENOIC ACID RETINAMIDES AS APOPTOSIS INDUCING COMPOUNDS AND THEIR USE AS ANTI-CANCER AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | disclosed |