Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | CASP6 | P55212 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | HCAR3 | P49019 | 6/20 | 0.54 |
| ▸ | CDC25B | P30305 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | EIF4E | P06730 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6555690 | 1.00 | POLB (0.59) | POLBCASP6TSHRLMNAHCAR3 | |
| SCHEMBL28512486 | 0.88 | EIF4E (0.56) | POLBCASP6TSHRLMNAHCAR3 | |
| Hydrochloric Acid SCHEMBL9784149 | 0.88 | CASP6 (0.62) | POLBCASP6TSHRLMNAHCAR3 | |
| SCHEMBL11195885 | 0.87 | CASP6 (0.75) | CASP6TSHRLMNAHCAR3 | |
| SCHEMBL3377807 | 0.85 | CASP6 (0.54) | POLBCASP6TSHRLMNAHCAR3 | |
| SCHEMBL4439669 | 0.84 | TSHR (0.59) | TSHRLMNAKDM4ESMN1; SMN2MAPT | |
| SCHEMBL2772166 | 0.84 | TSHR (0.65) | POLBCASP6TSHRLMNAHCAR3 | |
| SCHEMBL5216752 | 0.84 | EIF4E (0.56) | POLBTSHRLMNACDC25BSMN1; SMN2 | |
| SCHEMBL99918 | 0.83 | CASP6 (0.64) | POLBCASP6TSHRLMNAHCAR3 | |
| SCHEMBL29120749 | 0.82 | MAPT (0.57) | TSHRLMNAKDM4ESMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487800-A1 | PHENANTHRIDINONES AS PARP INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003080581-A1 | PHENANTHRIDINONES AS PARP INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-10-02 | — | — | WO | disclosed |