Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 3/20 | 0.39 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.38 |
| ▸ | PAK1 | Q13153 | 3/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.37 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.37 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.37 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 2/20 | 0.34 |
| ▸ | CCR3 | P51677 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | LGALS8 | O00214 | 1/20 | 0.33 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4008006 | 0.86 | YTHDC1 (0.45) | NTRK1YTHDC1CSNK2A1PAK1PRKAB2 | |
| SCHEMBL4008733 | 0.83 | APEX1 (0.46) | NTRK1CSNK2A1PAK1PRKAB2PRKAG1 | |
| SCHEMBL4005400 | 0.82 | APEX1 (0.46) | NTRK1YTHDC1CSNK2A1PAK1PRKAB2 | |
| SCHEMBL4008356 | 0.81 | YTHDC1 (0.53) | NTRK1YTHDC1CSNK2A1PAK1PRKAB2 | |
| SCHEMBL4008113 | 0.80 | APEX1 (0.49) | NTRK1CSNK2A1PAK1PRKAB2PRKAG1 | |
| SCHEMBL4008425 | 0.79 | PRKAG1 (0.40) | NTRK1CSNK2A1PRKAG1PRKAA1PRKAB1 | |
| SCHEMBL4009508 | 0.78 | NTRK1 (0.51) | NTRK1YTHDC1CSNK2A1PAK1PRKAA1 | |
| SCHEMBL4014969 | 0.77 | FLT3 (0.51) | CSNK2A1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL6554266 | 0.77 | CSNK2A1 (0.45) | NTRK1CSNK2A1PRKAA1CDK2FLT3 | |
| SCHEMBL6554271 | 0.77 | CSNK2A1 (0.45) | NTRK1CSNK2A1PRKAA1CDK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487803-A1 | INDAZOLES SUBSTITUTED WITH AN ANTI-CANCEROUS ACTIVITY | Aventis Pharma S.A. (FR) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003078402-A1 | INDAZOLES SUBSTITUTED WITH AN ANTI-CANCEROUS ACTIVITY | AVENTIS PHARMA S.A. (FR) | 2003-09-25 | — | — | WO | disclosed |