Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 16/20 | 0.56 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6556126 | 0.92 | ELANE (0.65) | ELANEP2RX3NPC1RAB9A | |
| SCHEMBL6556272 | 0.89 | ELANE (0.61) | ELANEP2RX3NPC1RAB9ACASP1 | |
| SCHEMBL6085892 | 0.87 | ELANE (0.60) | ELANEP2RX3NPC1RAB9A | |
| SCHEMBL6558347 | 0.84 | ELANE (0.58) | ELANEP2RX3NPC1RAB9ACASP1 | |
| SCHEMBL6556264 | 0.84 | ELANE (0.56) | ELANEP2RX3NPC1RAB9ACASP1 | |
| SCHEMBL6557626 | 0.83 | ELANE (0.54) | ELANEP2RX3NPC1RAB9A | |
| SCHEMBL6558401 | 0.83 | ELANE (0.56) | ELANEP2RX3NPC1RAB9A | |
| SCHEMBL6556223 | 0.83 | ELANE (0.62) | ELANEP2RX3NPC1RAB9A | |
| SCHEMBL6558159 | 0.83 | ELANE (0.63) | ELANE | |
| SCHEMBL8404952 | 0.82 | ELANE (0.52) | ELANEP2RX3NPC1RAB9ACYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0826671-B1 | HETEROCYCLIC AMIDE COMPOUNDS AND MEDICINAL USE OF THE SAME | MITSUBISHI PHARMA CORP (JP) | 2004-12-29 | — | — | EP | disclosed |
| US-5948785-A | USEFUL AS CHYMASE INHIBITORS AND CAN BE EFFECTIVE FOR THE PROPHYLAXIS AND TREATMENT OF VARIOUS DISEASES CAUSED BY CHYMASE, SUCH AS THOSE CAUSED BY ANGIOTENSIN II. | THE GREEN CROSS CORPORATION (JP) | 1999-09-07 | — | — | US | disclosed |
| EP-0826671-A1 | HETEROCYCLIC AMIDE COMPOUNDS AND MEDICINAL USE OF THE SAME | THE GREEN CROSS CORPORATION (JP) | 1998-03-04 | — | — | EP | disclosed |